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Indatuximab ravtansine

(Synonyms: nBT062-DM4, BT-062) Copy Product Info
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Synonyms: nBT062-DM4, BT-062

Catalog No. T9901A-224 Copy Product Info
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Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) (Antibody-Drug Conjugates (ADCs)) that consists of a murine-human chimeric form based on B-B4, which specifically targets CD138, linked via a disulfide bond to the maytansinoid drug DM4. It exhibits antitumor activity.

Indatuximab ravtansine

Cas No. 1238517-16-2
Pack SizePriceUSA StockGlobal StockQuantity
1 mgInquiryInquiryInquiry
5 mgInquiryInquiryInquiry
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) (Antibody-Drug Conjugates (ADCs)) that consists of a murine-human chimeric form based on B-B4, which specifically targets CD138, linked via a disulfide bond to the maytansinoid drug DM4. It exhibits antitumor activity.
In vitro
Indatuximab ravtansine demonstrated cytotoxic effects in RPMI 8226, MOLP-8, and U266 cell lines (with significant CD138 expression) at concentrations ranging from 1 pM to 100 nM over five days. The IC50 values for RPMI 8226, MOLP-8, and U266 were 200 pM, 40 pM, and 20 pM, respectively.
In vivo
Indatuximab ravtansine (5.3-21.2 mg/kg; intravenous injection; single dose) suppresses tumor growth in multiple myeloma and enhances host survival in vivo.
SynonymsnBT062-DM4, BT-062
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Antigen Details
TargetCD138
Chemical Properties
Cas No.1238517-16-2
Storage & Solubility Information
Storage-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Related Tags: Indatuximab ravtansine in vivo | Indatuximab ravtansine in vitro