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CIB-L43
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Catalog No. T205607Cas No. 1082942-70-8
Alias CIBL43
CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells.
CIB-L43
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Purity: 99.64%
Catalog No. T205607Alias CIBL43Cas No. 1082942-70-8
CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $64 | - | In Stock | |
| 5 mg | $153 | - | In Stock | |
| 10 mg | $247 | - | In Stock | |
| 25 mg | $495 | - | In Stock | |
| 50 mg | $793 | - | In Stock | |
| 100 mg | $1,190 | - | In Stock | |
| 200 mg | $1,630 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.64%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells. |
| Targets&IC50 | TRBP-Dicer interaction:2.34 μM, miR-21 biosynthesis (HCC cells):0.66 nM (EC50) |
| In vitro | CIB-L43, a 2-phenylthiazole-5-carboxylic acid derivative, binds TRBP with high affinity (KD = 4.78 nM) and disrupts the TRBP-Dicer interaction (IC₅₀ = 2.34 μM). In hepatocellular carcinoma cells, CIB-L43 suppresses oncogenic miR-21 biosynthesis with nanomolar potency (EC₅₀ = 0.66 nM), upregulates tumor suppressors PTEN and Smad7, inhibits AKT and TGF-β signaling, and significantly reduces cell proliferation and migration[1]. |
| In vivo | In hepatocellular carcinoma mouse models, CIB-L43 showed favorable pharmacokinetics, including an oral bioavailability of 53.9%[1]. |
| Synonyms | CIBL43 |
| Molecular Weight | 304.36 |
| Formula | C15H16N2O3S |
| Cas No. | 1082942-70-8 |
| Smiles | O=C(O)C=1SC(=NC1C)C=2C=CC(=CC2)N3CCOCC3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (16.43 mM), Sonication and heating are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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