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CIB-L43
🥰Excellent
Catalog No. T205607Cas No. 1082942-70-8
Alias CIBL43
CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells.
CIB-L43
🥰Excellent
Purity: 99.64%
Catalog No. T205607Alias CIBL43Cas No. 1082942-70-8
CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $70 | In Stock | |
| 5 mg | $156 | In Stock | |
| 10 mg | $249 | In Stock | |
| 25 mg | $507 | In Stock | |
| 50 mg | $813 | In Stock | |
| 100 mg | $1,220 | In Stock |
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Purity:99.64%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells. |
| Targets&IC50 | miR-21 biosynthesis (HCC cells):0.66 nM (EC50), TRBP-Dicer interaction:2.34 μM |
| In vitro | CIB-L43, a 2-phenylthiazole-5-carboxylic acid derivative, binds TRBP with high affinity (KD = 4.78 nM) and disrupts the TRBP-Dicer interaction (IC₅₀ = 2.34 μM). In hepatocellular carcinoma cells, CIB-L43 suppresses oncogenic miR-21 biosynthesis with nanomolar potency (EC₅₀ = 0.66 nM), upregulates tumor suppressors PTEN and Smad7, inhibits AKT and TGF-β signaling, and significantly reduces cell proliferation and migration[1]. |
| In vivo | In hepatocellular carcinoma mouse models, CIB-L43 showed favorable pharmacokinetics, including an oral bioavailability of 53.9%[1]. |
| Alias | CIBL43 |
| Molecular Weight | 304.36 |
| Formula | C15H16N2O3S |
| Cas No. | 1082942-70-8 |
| Smiles | O=C(O)C=1SC(=NC1C)C=2C=CC(=CC2)N3CCOCC3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.00 mg/mL (16.43 mM), Sonication and heating are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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