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K-604 dihydrochloride

🥰Excellent
Catalog No. T11733Cas No. 217094-32-1

K-604 dihydrochloride, a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor, exhibits an IC50 of 0.45±0.06 μM.

K-604 dihydrochloride

K-604 dihydrochloride

🥰Excellent
Purity: 99.74%
Catalog No. T11733Cas No. 217094-32-1
K-604 dihydrochloride, a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor, exhibits an IC50 of 0.45±0.06 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$51In StockIn Stock
2 mg$74In StockIn Stock
5 mg$122In StockIn Stock
10 mg$197In StockIn Stock
25 mg$397In StockIn Stock
50 mg$589In StockIn Stock
100 mg$843In StockIn Stock
1 mL x 10 mM (in DMSO)$169In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.74%
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Product Introduction

Bioactivity
Description
K-604 dihydrochloride, a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor, exhibits an IC50 of 0.45±0.06 μM.
Targets&IC50
ACAT1:0.45 μM, ACAT2:102.85 μM
In vitro
a novel ACAT inhibitor, K-604. The IC(50) values of K-604 for human ACAT-1 and ACAT-2 were 0.45 and 102.85 micromol/L, respectively, indicating that K-604 is 229-fold more selective for ACAT-1. Kinetic analysis indicated that the inhibition was competitive with respect to oleoyl-coenzyme A with a K(i) value of 0.378 micromol/L. Exposure of human monocyte-derived macrophages to K-604 inhibited cholesterol esterification with IC(50) of 68.0 nmol/L. Furthermore, cholesterol efflux from THP-1 macrophages to HDL(3) or apolipoprotein A-I was enhanced by K-604[1].
Chemical Properties
Molecular Weight575.64
FormulaC23H32Cl2N6OS3
Cas No.217094-32-1
SmilesCl.Cl.CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccccc3[nH]2)CC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 62.5 mg/mL (108.57 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.34 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7372 mL8.6860 mL17.3720 mL86.8598 mL
5 mM0.3474 mL1.7372 mL3.4744 mL17.3720 mL
10 mM0.1737 mL0.8686 mL1.7372 mL8.6860 mL
20 mM0.0869 mL0.4343 mL0.8686 mL4.3430 mL
50 mM0.0347 mL0.1737 mL0.3474 mL1.7372 mL
100 mM0.0174 mL0.0869 mL0.1737 mL0.8686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

mono- acylglycerol acyltransferaseK-604 DihydrochlorideK604 DihydrochlorideK604 dihydrochlorideK-604K604K 604 DihydrochlorideK 604 dihydrochlorideK 604InhibitorinhibitDiglyceride acyltransferaseDiacylglycerol acyltransferaseAcyltransferaseacyl-CoA:cholesterol acyltransferaseACAT-2ACAT-1
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