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Anti-gp130/IL6ST Antibody (7J799)

😃Good
Catalog No. TMAY-03136
Alias interleukin 6 signal transducer, IL-6RB, GP130, CDW130, CD130

Anti-gp130/IL6ST Antibody (7J799) is a Rabbit antibody targeting gp130/IL6ST. Anti-gp130/IL6ST Antibody (7J799) can be used in FCM.

Anti-gp130/IL6ST Antibody (7J799)

Anti-gp130/IL6ST Antibody (7J799)

😃Good
Catalog No. TMAY-03136Alias interleukin 6 signal transducer, IL-6RB, GP130, CDW130, CD130
Anti-gp130/IL6ST Antibody (7J799) is a Rabbit antibody targeting gp130/IL6ST. Anti-gp130/IL6ST Antibody (7J799) can be used in FCM.
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100 μL$268 7-10 days
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Instruction Manual of Detection Antibody
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Product Introduction

Bioactivity
Description
Antibody Type: Rabbit Monoclonal

Application: FCM

Reactivity: Mouse
Aliasinterleukin 6 signal transducer, IL-6RB, GP130, CDW130, CD130
Ig Type
Rabbit IgG
Clone
7J799
Reactivity
Mouse
Verified Activity
Flow cytometric analysis of Mouse IL6ST(CD130) expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse IL6ST(CD130), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
FCM: 1:25-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL6ST/gp130/CD130 (rM IL6ST/gp130/CD130; TMPY-01832; NP_034690.3; Met1-Glu617).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundGlycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
APC/PE
Antibody Types Available
3
Antigen Details
Immunogen
Recombinant Protein: Mouse IL6ST/gp130/CD130 Protein (TMPY-01832)
Antigen Species
Mouse
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GP-130GP 130CDW-130CDW 130CD-130CD 130
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