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Fasnall HCl

Name: Fasnall HCl
Brand: TargetMol
SKU: T27307L
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27307L

Alias Fasnall HCl(929978-58-5 Free base)

Fasnall HCl is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall HCl also shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) breast cancer, particularly when combined with carboplatin.

Fasnall HCl

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Purity: 99.97%

Catalog No. T27307LAlias Fasnall HCl(929978-58-5 Free base)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	-	In Stock
5 mg	$208	-	In Stock
10 mg	$335	-	In Stock
25 mg	$529	-	In Stock
50 mg	$738	-	In Stock
100 mg	$996	-	In Stock
200 mg	$1,330	-	In Stock
1 mL x 10 mM (in DMSO)	$233	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Fasnall HCl is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall HCl also shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) breast cancer, particularly when combined with carboplatin.
Targets&IC50	FASN:3.71 μM
In vitro	Fasnall HCl potently blocked both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells. Fasnall HCl inhibited FASN with IC50 values of 3.71 μM in vitro. The molecules were tested in the acetate incorporation assay in BT474 cells. Fasnall HCl is able to inhibit the incorporation of tritiated acetate (IC50 5.84 μM, respectively) into lipids [1].
In vivo	FVB/J mice received 5, 20, or 80 mg/kg Fasnall HCl via intraperitoneal injection on days 1 and 3. Fasnall HCl was toxic at 80 mg/kg, but at 5–20 mg/kg was well tolerated with no adverse effects on white blood cell counts, hemoglobin levels, kidney, or liver functions. Cohorts of MMTV-Neu mice were treated with a biweekly intraperitoneal injection of 15 mg/kg Fasnall HCl, shows that Fasnall HCl reduced tumor volume compared with vehicle-treated animals [1].
Synonyms	Fasnall HCl(929978-58-5 Free base)

Chemical Properties

Molecular Weight	374.93
Formula	C₁₉H₂₃ClN₄S
Smiles	CC1=C(C)SC2=NC=NC(NC3CN(CC3)CC4=CC=CC=C4)=C21.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (60.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6672 mL	13.3358 mL	26.6716 mL	133.3582 mL
5 mM	0.5334 mL	2.6672 mL	5.3343 mL	26.6716 mL
10 mM	0.2667 mL	1.3336 mL	2.6672 mL	13.3358 mL
20 mM	0.1334 mL	0.6668 mL	1.3336 mL	6.6679 mL
50 mM	0.0533 mL	0.2667 mL	0.5334 mL	2.6672 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc