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Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.

  • SIRT1-IN-1
    T9648352554-02-0In house
    SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity.
    • $97
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  • Nicotinamide riboside
    T137951341-23-7
    Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.
    • $50
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  • WAY-270360
    T60064476633-98-4
    WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.
    • $58
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  • SRT 1720 dihydrochloride[925434-55-5(free base)]
    T5124
    SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
    • $56
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  • MC2184
    T5008074901-20-5
    MC2184 is the inhibitor of human recombinant SIRT1.
    • $129
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  • WAY-323061
    T77605550301-63-8
    WAY-323061 is a SIRT2 inhibitor.
    • $195
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  • Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
    T60001863589-52-0
    Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including diabetes, cardiovascular disease, bloo
    • $85
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  • SIRT6-IN-5
    T24793891002-11-2In house
    SIRT6-IN-5(SIRT6 inhibitor 5) is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, and reduces T-cell proliferation.
    • $51
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  • SIRT5 inhibitor 1
    T129212166487-21-2In house
    SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases.
    • $148
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  • Sirt2-IN-1
    T129201862238-00-3In house
    Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).
    • $107
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  • JGB1741
    T220941256375-38-8In house
    JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-mediated apoptosis. JGB1741 can be used in studies about breast cancer.
    • $54
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  • MC3482
    T119622922280-86-0In house
    MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
    • $48
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  • RK-9123016
    T28543955900-27-3In house
    RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
    • $50
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  • Resveratrol
    T1558501-36-0
    Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
    • $36
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  • Scopolin
    T3888531-44-2
    Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.
    • $110
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  • SRT 2183
    T169321001908-89-9
    SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
    • $46
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  • Selisistat
    T611149843-98-3
    Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea.
    • $43
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  • Sirtinol
    T6671410536-97-9
    Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
    • $36
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  • UBCS039
    T7679358721-70-7
    UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
    • $56
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  • Nicotinamide
    T093498-92-0
    • $50
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  • 3-TYP
    T4108120241-79-4
    3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
    • $52
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  • Suramin Sodium Salt
    T2160129-46-4
    Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
    • $41
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  • Fisetin
    T2879528-48-3
    Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects.
    • $41
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  • Ganoderic acid D
    T5S1133108340-60-9
    1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 microM.
    • $39
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  • Tenovin-3
    T18731011301-27-1
    Tenovin-3 acts as a p53 activator.
    • $55
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  • Inauhzin
    T1887309271-94-1
    Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
    • $35
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  • SRT 1720
    T5096925434-55-5
    SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
    • $33
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  • SRT1720 hydrochloride
    T24121001645-58-4
    SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
    • $63
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  • BML-278
    T77697120533-76-8
    BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 induces cell cycle arrest in primary human mesenchymal stromal cells at the G1/S phase, and can be used to delay senescence.BML-278 reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts. BML-278 reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.
    • $58
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  • SIRT6-IN-3
    T796893023471-40-8
    SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to gemcitabine by obstructing the DNA damage repair pathway, thus serving as a valuable tool in pancreatic cancer research [1].
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  • MDL-811
    T818312275619-98-0
    MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac), presenting potential utility in colorectal cancer research [1].
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  • Epigenetic factor-IN-1
    T824582640673-56-7
    Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7. It is utilized in the study of liver cancer [1].
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  • MIND4-19
    T9998129544-85-0
    MIND4-19 is an inhibitor of SIRT2 with antitumor activity.
    • $67
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  • (+)-Syringaresinol
    TN224921453-69-0
    (+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
    • $1,190
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  • Sirtuin modulator 2
    T9999667910-69-2
    Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.
    • $41
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  • YK-3-237
    T93201215281-19-8
    YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53.
    • $34
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  • PROTAC Sirt2 Degrader-1
    T166672098487-75-1
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
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  • YM-08
    T80752812647-88-4
    YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].
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  • Selisistat S-enantiomer
    T7058848193-68-0
    Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.
    • $153
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  • AK-1
    T5618330461-64-8
    AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.
    • $30
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  • WAY-354574
    T80813851873-40-0
    WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].
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  • B2
    T22595115687-05-3
    B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease
    • $68
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  • SIRT1 activator 1
    T81154
    SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp. mangrove fungus, exhibits angiogenic effects in zebrafish and protects human endothelial progenitor cells (hEPCs) from AngII-induced senescence. It achieves this by elevating SIRT1 expression and modulating the AMPK/Akt signaling pathway [1].
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  • HSP70/SIRT2-IN-1
    T82168
    HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2. This compound possesses antitumor activity [1].
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  • SIRT5 inhibitor 8
    T78856
    SIRT5 inhibitor 8 (compound 10) serves as a competitive inhibitor of sirtuin SIRT5, exhibiting an IC50 of 5.38 μM, and possesses anticancer potential [1].
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  • SIRT5 inhibitor 9
    T78857
    SIRT5 inhibitor 9 (compound 14), with an IC50 of 4.07 μM, is a competitive inhibitor of the sirtuin SIRT5, exhibiting potential anticancer properties [1].
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  • Sirt1/2-IN-2
    T79563670267-73-9
    Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines [1].
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  • Sirt1/2-IN-4
    T79565
    Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respectively. It effectively inhibits p53 deacetylation, indicating potential anticancer properties [1].
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  • Agrimol B
    T4S117355576-66-4
    1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
    • $116
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  • SIRT7 inhibitor 97491
    T392331807758-81-1
    SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
    • $97
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