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β-Nicotinamide mononucleotide, reduced form disodium
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Catalog No. TN11626Cas No. 108347-85-9
Alias NMNH disodium
β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is the reduced variant of β-Nicotinamide mononucleotide, with oral bioavailability. This compound significantly increases NAD+ and NADH levels while inhibiting glycolysis, the tricarboxylic acid cycle, and cell growth, mechanisms that are dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT).
β-Nicotinamide mononucleotide, reduced form disodium
Copy Product Info😃Good
Catalog No. TN11626Alias NMNH disodiumCas No. 108347-85-9
β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is the reduced variant of β-Nicotinamide mononucleotide, with oral bioavailability. This compound significantly increases NAD+ and NADH levels while inhibiting glycolysis, the tricarboxylic acid cycle, and cell growth, mechanisms that are dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
Storage & Solubility Information
| Description | β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is the reduced variant of β-Nicotinamide mononucleotide, with oral bioavailability. This compound significantly increases NAD+ and NADH levels while inhibiting glycolysis, the tricarboxylic acid cycle, and cell growth, mechanisms that are dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT). |
| In vitro | β-Nicotinamide mononucleotide, reduced form (100 μM; 12 h) disodium significantly increases NAD+ levels in HepG2 cells while decreasing metabolites of glycolysis and the TCA cycle. At concentrations of 250-1000 μM over 12-72 hours, β-Nicotinamide mononucleotide, reduced form disodium inhibits HepG2 cell growth and induces cell cycle arrest. |
| In vivo | The administration of β-Nicotinamide mononucleotide, reduced form (340 mg/kg; Intraperitoneal injection / gavage; Single time) disodium, increases NAD+ levels in the liver of male mice. Additionally, a dosage of β-Nicotinamide mononucleotide, reduced form (250 mg/kg; Intraperitoneal injection; Single time) disodium elevates NAD+ levels by 2-5 times in the liver, kidneys, brain, muscles, and whole blood of C57BL/6J mice. |
| Synonyms | NMNH disodium |
| Molecular Weight | 380.20 |
| Formula | C11H15N2Na2O8P |
| Cas No. | 108347-85-9 |
| Smiles | O[C@H]1[C@H](N2C=C(CC=C2)C(N)=O)O[C@@H]([C@H]1O)COP([O-])([O-])=O.[Na+].[Na+] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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