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Tioxolone

Name: Tioxolone
Brand: TargetMol
SKU: T0515
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0515Cas No. 4991-65-5

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.

Tioxolone

😃Good

Purity: 97.79%

Catalog No. T0515Cas No. 4991-65-5

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.

Pack Size	Price	Availability
1 g	$34	In Stock
5 g	$78	In Stock
10 g	$115	Backorder
1 mL x 10 mM (in DMSO)	$30	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.79%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
Targets&IC50	CA I:91 nM(Ki)
In vitro	Tioxolone, along with its Benzoxathiol derivatives, exhibits antibacterial and antifungal properties, as well as inhibitory effects on cell proliferation. These compounds have been utilized in topical treatments for common psoriasis and acne.
In vivo	Tioxolone exhibits sebum-regulating and antibacterial properties, thus it is incorporated in various cosmetics such as shampoos and skin cleansers.

Chemical Properties

Molecular Weight	168.17
Formula	C₇H₄O₃S
Cas No.	4991-65-5
Smiles	OC1=CC=C2SC(=O)OC2=C1
Relative Density.	1.4844 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 32 mg/mL (190.28 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 45 mg/mL (267.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9464 mL	29.7318 mL	59.4636 mL	297.3182 mL
5 mM	1.1893 mL	5.9464 mL	11.8927 mL	59.4636 mL
10 mM	0.5946 mL	2.9732 mL	5.9464 mL	29.7318 mL
20 mM	0.2973 mL	1.4866 mL	2.9732 mL	14.8659 mL
50 mM	0.1189 mL	0.5946 mL	1.1893 mL	5.9464 mL
100 mM	0.0595 mL	0.2973 mL	0.5946 mL	2.9732 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc