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Eledoisin

Name: Eledoisin
Brand: TargetMol
SKU: TP1177
Rating: 4.5 (1 reviews)

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Catalog No. TP1177Cas No. 69-25-0

Alias Eledone peptide

Eledoisin (Eledone peptide) is an undecapeptide of mollusk origin in the tachykinin family of neuropeptides, serving as a specific agonist of NK2 and NK3 receptors.

Eledoisin

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Catalog No. TP1177Alias Eledone peptideCas No. 69-25-0

Eledoisin (Eledone peptide) is an undecapeptide of mollusk origin in the tachykinin family of neuropeptides, serving as a specific agonist of NK2 and NK3 receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$297	35 days	35 days
5 mg	$1,180	35 days	35 days
10 mg	$2,130	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Eledoisin (Eledone peptide) is an undecapeptide of mollusk origin in the tachykinin family of neuropeptides, serving as a specific agonist of NK2 and NK3 receptors.
In vitro	Eledoisin increases basal activity by 24.5±3.7%; however, its stimulation is significantly reduced to 13.1±1.9% in the presence of CP99994 (P<0.01). This effect demonstrates the compound's sensitivity to CP99994, further validated through similar tests with 0.1 μM SR48968 and 0.1 μM SB222200. SR48968 significantly decreases Eledoisin's effect (P<0.01), whereas SB222200 does not alter it. This data collectively indicates that Eledoisin's stimulatory action is diminished by CP99994 and SR48968, which are NK1 and NK2 antagonists, respectively[1].
In vivo	Injection of Eledoisin (0.1-1 nmol/kg) into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg).
Synonyms	Eledone peptide

Chemical Properties

Molecular Weight	1188.4
Formula	C₅₄H₈₅N₁₃O₁₅S
Cas No.	69-25-0
Smiles	CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C1CCCN1C(=O)C1CCC(=O)N1)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O
Relative Density.	1.289 g/cm3
Sequence	{Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2
Sequence Short	{Glp}-PSKDAFIGLM

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 18.15 mg/mL (15.27 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.8415 mL	4.2073 mL	8.4147 mL	42.0734 mL
5 mM	0.1683 mL	0.8415 mL	1.6829 mL	8.4147 mL
10 mM	0.0841 mL	0.4207 mL	0.8415 mL	4.2073 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc