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Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-00479
Synonyms: ARIA, neuregulin 1, GGF2, MSTP131, GGF, MST131, HGL, NDF, SMDF, HRG1, HRGA, HRG, NRG1-IT2

Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.5 kDa and the accession number is Q02297-12.

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Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc)
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100 μg 5 days $ 462.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.5 kDa and the accession number is Q02297-12.
Species Human
Expression System HEK293 Cells
Tag N-hFc
Accession Number Q02297-12
Synonyms ARIA, neuregulin 1, GGF2, MSTP131, GGF, MST131, HGL, NDF, SMDF, HRG1, HRGA, HRG, NRG1-IT2
Construction The Human NRG1 (NP_001153480.1) (Ser177-Gln237) was expressed with the Fc region of Human IgG1 at the N-terminus.
Protein Purity > 90 % as determined by SDS-PAGE.
Molecular Weight 35.5 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

References and Literature

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Keywords

Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) ARIA MST 131 neuregulin 1 MSTP 131 MST-131 GGF2 MSTP131 GGF MST131 HGL NDF GGF-2 SMDF HRG1 GGF 2 HRGA HRG NRG1-IT2 HRG-1 MSTP-131 HRG 1 recombinant recombinant-proteins proteins protein

 

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