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Iodipamide

Name: Iodipamide
Brand: TargetMol
SKU: T0271
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0271Cas No. 606-17-7

Alias Iodipamic acid, Adipiodone

Iodipamide (Iodipamic acid) is a water-soluble radiographic contrast media for intravenous cholangiography and cholecystography.

Iodipamide

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Purity: 99.75%

Catalog No. T0271Alias Iodipamic acid, AdipiodoneCas No. 606-17-7

Iodipamide (Iodipamic acid) is a water-soluble radiographic contrast media for intravenous cholangiography and cholecystography.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$61	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$155	In Stock	In Stock
100 mg	$216	In Stock	In Stock
200 mg	$280	In Stock	In Stock
500 mg	$469	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Iodipamide AI Summary

Iodipamide demonstrates a variety of bioactivities and interactions across multiple biological pathways and systems. As an inhibitor of Cholesteryl Ester Transfer Protein (CETP) in rabbit serum, it shows a 15.9% inhibition rate at 10 μM concentration. It also acts as an agonist of the Thyroid Stimulating Hormone Receptor with a potency of 6309.6 nM, inhibits the ERK Signaling Pathway at 1258.9 nM, and blocks HP1-beta Chromodomain interactions at 79432.8 nM. Additionally, it exhibits gametocytocidal activity at 35481.3 nM and inhibits Ebola virus entry with AC50 values ranging from 0.631 μM to 8912.5 nM. In terms of liver-related bioactivity, Iodipamide has shown no hepatic side effects in the Drug Induced Liver Injury Prediction System (DILIps) training set, yet clinical observations indicate moderate liver toxicity, including acute liver toxicity, cytolytic liver toxicity, and steatosis. It significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells by 90.55% and 60.87% respectively, at 10 μM concentration. In antiviral assays, Iodipamide inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 41.36% at 10 μM after 48 hours, though it shows a mixed profile against SARS-CoV-2 in other assays. It has an 11.2% inhibition rate against SARS-CoV-2 3CL-Pro protease activity at 20 μM. Against SARS-CoV-2, it shows no significant cytotoxicity inhibition in VERO-6 cells at 10 μM, while presenting an IC50 value greater than 20000.0 nM for cytotoxicity inhibition. Further bioactivity includes minimal inhibitory effects on human HDAC6 with 1.66% and 7.68% inhibition in enzymatic assays. Iodipamide also exhibits binding affinities towards receptors and enzymes such as OPRM1, HRH2, DRD1, CHRM2, HTR1A, ADRA2A, PGR, HTR2A, and HTR2B, and other targets including KCNH2, Cacna1c, ADRB1, ADRB2, and SLC6A3, albeit generally with high AC50 values indicating low binding affinities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Iodipamide (Iodipamic acid) is a water-soluble radiographic contrast media for intravenous cholangiography and cholecystography.
Synonyms	Iodipamic acid, Adipiodone

Chemical Properties

Molecular Weight	1139.76
Formula	C₂₀H₁₄I₆N₂O₆
Cas No.	606-17-7
Smiles	OC(=O)c1c(I)cc(I)c(NC(=O)CCCCC(=O)Nc2c(I)cc(I)c(C(O)=O)c2I)c1I
Relative Density.	2.8g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 125 mg/mL (109.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (3.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8774 mL	4.3869 mL	8.7738 mL	43.8689 mL
5 mM	0.1755 mL	0.8774 mL	1.7548 mL	8.7738 mL
10 mM	0.0877 mL	0.4387 mL	0.8774 mL	4.3869 mL
20 mM	0.0439 mL	0.2193 mL	0.4387 mL	2.1934 mL
50 mM	0.0175 mL	0.0877 mL	0.1755 mL	0.8774 mL
100 mM	0.0088 mL	0.0439 mL	0.0877 mL	0.4387 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc