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SKA-111
🥰Excellent
Catalog No. T24799Cas No. 1369170-24-0
Alias SKA111, SKA 111
SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases.
SKA-111
🥰Excellent
Purity: 99.9%
Catalog No. T24799Alias SKA111, SKA 111Cas No. 1369170-24-0
SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $155 | In Stock | |
| 10 mg | $263 | In Stock | |
| 25 mg | $530 | In Stock | |
| 50 mg | $766 | In Stock | |
| 100 mg | $1,070 | In Stock | |
| 500 mg | $2,150 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $170 | In Stock |
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Purity:99.9%
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Product Introduction
Bioactivity
Chemical Properties
| Description | SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases. |
| In vitro | SKA-111 (1 μM; 5 min) causes KCa3.1 membrane hyperpolarization in porcine endothelial cells. SKA-111 induces significantly enhanced Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in porcine large coronary arteries (PCA).[1] |
| In vivo | SKA-111 (1 μM; Cardiac perfusion; Langendorff in rat hearts; ) improves Bradykinin-induced coronary artery dilation in isolated rat hearts. SKA-111 potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.[1] |
| Synonyms | SKA111, SKA 111 |
| Molecular Weight | 214.29 |
| Formula | C12H10N2S |
| Cas No. | 1369170-24-0 |
| Smiles | NC1=NC=2C=3C(C(C)=CC2S1)=CC=CC3 |
| Relative Density. | 1.348 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 65 mg/mL (303.33 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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