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SKA-111

Name: SKA-111
Brand: TargetMol
SKU: T24799
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T24799Cas No. 1369170-24-0

Alias SKA111, SKA 111

SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases.

SKA-111

🥰Excellent

Purity: 99.9%

Catalog No. T24799Alias SKA111, SKA 111Cas No. 1369170-24-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	-	In Stock
5 mg	$155	-	In Stock
10 mg	$263	-	In Stock
25 mg	$530	-	In Stock
50 mg	$766	-	In Stock
100 mg	$1,070	-	In Stock
500 mg	$2,150	-	In Stock
1 mL x 10 mM (in DMSO)	$170	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases.
In vitro	SKA-111 (1 μM; 5 min) causes KCa3.1 membrane hyperpolarization in porcine endothelial cells. SKA-111 induces significantly enhanced Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in porcine large coronary arteries (PCA).[1]
In vivo	SKA-111 (1 μM; Cardiac perfusion; Langendorff in rat hearts; ) improves Bradykinin-induced coronary artery dilation in isolated rat hearts. SKA-111 potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.[1]
Synonyms	SKA111, SKA 111

Chemical Properties

Molecular Weight	214.29
Formula	C₁₂H₁₀N₂S
Cas No.	1369170-24-0
Smiles	NC1=NC=2C=3C(C(C)=CC2S1)=CC=CC3
Relative Density.	1.348 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (303.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6666 mL	23.3329 mL	46.6657 mL	233.3287 mL
5 mM	0.9333 mL	4.6666 mL	9.3331 mL	46.6657 mL
10 mM	0.4667 mL	2.3333 mL	4.6666 mL	23.3329 mL
20 mM	0.2333 mL	1.1666 mL	2.3333 mL	11.6664 mL
50 mM	0.0933 mL	0.4667 mL	0.9333 mL	4.6666 mL
100 mM	0.0467 mL	0.2333 mL	0.4667 mL	2.3333 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc