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Febuxostat Acyl Glucuronide (Synonyms: Febuxostat acyl-β-D-glucuronide)
Catalog No. T35621 Copy Product Info
Purity: 98%
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Febuxostat Acyl Glucuronide is the primary metabolite of the potent xanthine oxidase (XO) inhibitor Febuxostat. It is formed through the glucuronidation of the carboxylic acid group of Febuxostat, a process mediated by UDP-glucuronosyltransferase (UGT) enzymes. The production of this acyl glucuronide is a major elimination pathway for the parent drug. Researching this metabolite is essential for characterizing metabolic clearance, understanding drug-drug interactions, and evaluating the pharmacokinetic variability of Febuxostat across different patient populations, including those with UGT enzymatic polymorphisms.
Febuxostat Acyl Glucuronide
Copy Product Info🥰Excellent
Catalog No. T35621
Synonyms Febuxostat acyl-β-D-glucuronide
Febuxostat Acyl Glucuronide is the primary metabolite of the potent xanthine oxidase (XO) inhibitor Febuxostat. It is formed through the glucuronidation of the carboxylic acid group of Febuxostat, a process mediated by UDP-glucuronosyltransferase (UGT) enzymes. The production of this acyl glucuronide is a major elimination pathway for the parent drug. Researching this metabolite is essential for characterizing metabolic clearance, understanding drug-drug interactions, and evaluating the pharmacokinetic variability of Febuxostat across different patient populations, including those with UGT enzymatic polymorphisms.
Cas No. 1351692-92-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 500 μg | $198 | 35 days | 35 days | |
| 2500 μg | $890 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98%
Appearance:Solid
Color:White
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| Description | Febuxostat Acyl Glucuronide is the primary metabolite of the potent xanthine oxidase (XO) inhibitor Febuxostat. It is formed through the glucuronidation of the carboxylic acid group of Febuxostat, a process mediated by UDP-glucuronosyltransferase (UGT) enzymes. The production of this acyl glucuronide is a major elimination pathway for the parent drug. Researching this metabolite is essential for characterizing metabolic clearance, understanding drug-drug interactions, and evaluating the pharmacokinetic variability of Febuxostat across different patient populations, including those with UGT enzymatic polymorphisms. |
| In vitro | Febuxostat Acyl Glucuronide, primarily formed by UGT1A1/1A3/1A8/1A9, shows minimal XO inhibition, confirming glucuronidation as a major inactivation pathway. Due to its reactivity as an acyl glucuronide, it is studied for acyl migration and covalent protein binding to assess potential immunogenicity or toxicity [1]. |
| Synonyms | Febuxostat acyl-β-D-glucuronide |
| Molecular Weight | 492.5 |
| Formula | C22H24N2O9S |
| Cas No. | 1351692-92-6 |
| Smiles | C(O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O)(=O)C=2SC(=NC2C)C3=CC(C#N)=C(OCC(C)C)C=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Methanol: Soluble DMSO: Soluble |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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