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COX-2-IN-34

Name: COX-2-IN-34
Brand: TargetMol
SKU: T77618
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77618Cas No. 2788578-71-0

COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.

COX-2-IN-34

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Purity: 97.17%

Catalog No. T77618Cas No. 2788578-71-0

COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$129	-	In Stock
5 mg	$293	-	In Stock
10 mg	$435	-	In Stock
25 mg	$676	-	In Stock
50 mg	$928	-	In Stock
100 mg	$1,230	-	In Stock
200 mg	$1,660	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.17%

Appearance:Solid

Color:Red

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.
Targets&IC50	COX-1:34.86 μM, COX-2:0.42 μM
In vitro	COX-2-IN-34 (compound 8a) (100 μM, 24 h) shows no significant cytotoxicity on RAW264.7 cells.[1] It selectively inhibits COX-1 and COX-2 activities with IC50 values of 34.86 and 0.42 μM, respectively, and at 10 μM, inhibits COX-2 by 82%.[1]
In vivo	COX-2-IN-34 (compound 8a) (50 mg/kg; orally; 3 days; rats) exhibits no gastric ulcer toxicity in a normal male rat model. COX-2-IN-34 (50 mg/kg; s.c.; rats) shows significant reduction in edema claw volume at 0, 1, 2, 3, 4, and 6 hours post-carrageenan injection compared to the control, with 42.90% and 45.95% inhibition at the 3rd and 4th hour, respectively, closely matching Celecoxib's 45.18% inhibition at 3 hours, demonstrating significant anti-inflammatory effects in carrageenan-induced plantar edema in rats.[1]

Chemical Properties

Molecular Weight	245.23
Formula	C₁₃H₁₁NO₄
Cas No.	2788578-71-0
Smiles	C(NC1=C(O)C=CC=C1)(=O)C2=C(O)C(O)=CC=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (183.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0778 mL	20.3890 mL	40.7780 mL	203.8902 mL
5 mM	0.8156 mL	4.0778 mL	8.1556 mL	40.7780 mL
10 mM	0.4078 mL	2.0389 mL	4.0778 mL	20.3890 mL
20 mM	0.2039 mL	1.0195 mL	2.0389 mL	10.1945 mL
50 mM	0.0816 mL	0.4078 mL	0.8156 mL	4.0778 mL
100 mM	0.0408 mL	0.2039 mL	0.4078 mL	2.0389 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc