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Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3
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Catalog No. TMAB-11195
Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-PTPN11 (Tyr542). Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3
Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3
😃Good
Catalog No. TMAB-11195
Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-PTPN11 (Tyr542). Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-PTPN11 (Tyr542). Anti-Phospho-PTPN11 (Tyr542) Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain, and skeletal muscle. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human PTPN11 around the phosphorylation site of Tyr542 |
| Antigen Species | Human |
| Gene Name | PTPN11 |
| Gene ID | |
| Protein Name | Tyrosine-protein phosphatase non-receptor type 11 |
| Uniprot ID | |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. |
| Molecular Weight | Theoretical: 66 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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