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T 162559

Name: T 162559
Brand: TargetMol
SKU: T213411
Rating: 4.5 (1 reviews)

Catalog No. T213411 Copy Product Info

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T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isozyme NHE1, with an IC50 value of 0.96 nM. It does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be utilized in cardiovascular disease research.

T 162559

Copy Product Info

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Catalog No. T213411

T 162559

Cas No. 339532-12-6

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isozyme NHE1, with an IC50 value of 0.96 nM. It does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be utilized in cardiovascular disease research.
In vitro	T-162559, when continuously infused at 10-100 nmol/L starting 10 minutes before the induction of global ischemia, inhibits the decline in myocardial contractility, the progression of cardiac systole, and the release of lactate dehydrogenase following global ischemia-reperfusion in a concentration-dependent manner.
In vivo	T-162559 (administered intravenously at 0.03-0.1 mg/kg, 5 minutes before coronary occlusion) significantly inhibits the progression of myocardial infarction induced by left coronary artery occlusion and reperfusion in rabbits.

Chemical Properties

Molecular Weight	517.59
Formula	C₂₀H₂₈FN₅O₆S₂
Cas No.	339532-12-6
Smiles	CS(=O)(O)=O.CC1=C(C=C(C=C1)F)[C@@H]2C/C(C3=C(C)C=CN=C3C2)=N\NC(N)=N.CS(=O)(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc