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Anti-MOB4A/MOB1B Antibody (6O289)
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Catalog No. TMAY-02681
Alias MOBKL1A, MOB4A, MOB kinase activator 1B, MATS2
Anti-MOB4A/MOB1B Antibody (6O289) is a Mouse antibody targeting MOB4A/MOB1B. Anti-MOB4A/MOB1B Antibody (6O289) can be used in ICC/IF.
Anti-MOB4A/MOB1B Antibody (6O289)
Anti-MOB4A/MOB1B Antibody (6O289)
😃Good
Catalog No. TMAY-02681Alias MOBKL1A, MOB4A, MOB kinase activator 1B, MATS2
Anti-MOB4A/MOB1B Antibody (6O289) is a Mouse antibody targeting MOB4A/MOB1B. Anti-MOB4A/MOB1B Antibody (6O289) can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ICC/IF Reactivity: Human |
| Alias | MOBKL1A, MOB4A, MOB kinase activator 1B, MATS2 |
| Ig Type | Mouse IgG2a |
| Clone | 6O289 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of Human MOBKL1A in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with mouse anti-Human MOBKL1A monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody(green) and counterstained with DAPI(blue). Positive staining was localized to cytoplasm. |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was obtained from a mouse immunized with purified, recombinant Human MOB1B / MOBKL1A (rh MOB1B / MOBKL1A; TMPY-03442; Q7L9L4; Met1-Arg216). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MOB1B and MOBKL1B polypeptides, homologs of the Drosophila MATS polypeptide, are identified as preferred MST1/MST2 substrates in vitro and are phosphorylated in cells in an MST1/MST2-dependent manner in mitosis and response to okadaic acid or H2O2. MST1/MST2-catalyzed MOB1B/MOBKL1B phosphorylation alters the ability of MOB1B/MOBKL1B to bind and regulate downstream targets such as the NDR-family protein kinases. Thus, MOB1B/MOBKL1B phosphorylation in cells promotes MOB1B/MOBKL1B binding to the LATS1 kinase and enables H2O2-stimulated LATS1 activation loop phosphorylation. Most importantly, the replacement of endogenous MOB1B/MOBKL1B by a non-phosphorylatable mutant is sufficient to accelerate cell proliferation substantially by speeding progression through G1/S as well as mitotic exit. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human MOB1B / MOBKL1A Protein (TMPY-03442) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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