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Gallopamil

Name: Gallopamil
Brand: TargetMol
SKU: T11353
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11353Cas No. 16662-47-8

Alias Methoxyverapamil

Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist.

Gallopamil

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Purity: 99.85%

Catalog No. T11353Alias MethoxyverapamilCas No. 16662-47-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$297	-	In Stock
100 mg	$453	-	In Stock
500 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$77	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.85%

Appearance:Viscous

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist.
In vivo	Gallopamil(5 min) significantly reduces systolic and diastolic blood pressure measured without markedly influencing heart rate. Gallopamil (0.2 mg/kg;i.v.) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF)[2].
Synonyms	Methoxyverapamil

Chemical Properties

Molecular Weight	484.63
Formula	C₂₈H₄₀N₂O₅
Cas No.	16662-47-8
Smiles	C(CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C(OC)=C2
Relative Density.	1.068 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (196.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0634 mL	10.3171 mL	20.6343 mL	103.1715 mL
5 mM	0.4127 mL	2.0634 mL	4.1269 mL	20.6343 mL
10 mM	0.2063 mL	1.0317 mL	2.0634 mL	10.3171 mL
20 mM	0.1032 mL	0.5159 mL	1.0317 mL	5.1586 mL
50 mM	0.0413 mL	0.2063 mL	0.4127 mL	2.0634 mL
100 mM	0.0206 mL	0.1032 mL	0.2063 mL	1.0317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc