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Gallopamil

Name: Gallopamil
Brand: TargetMol
SKU: T11353
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11353Cas No. 16662-47-8

Alias Methoxyverapamil

Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist.

Gallopamil

🥰Excellent

Purity: 99.85%

Catalog No. T11353Alias MethoxyverapamilCas No. 16662-47-8

Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$198	In Stock
50 mg	$297	In Stock
100 mg	$453	In Stock
500 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.85%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist.
In vivo	Gallopamil(5 min) significantly reduces systolic and diastolic blood pressure measured without markedly influencing heart rate. Gallopamil (0.2 mg/kg;i.v.) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF)[2].
Synonyms	Methoxyverapamil

Chemical Properties

Molecular Weight	484.63
Formula	C₂₈H₄₀N₂O₅
Cas No.	16662-47-8
Smiles	C(CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C(OC)=C2
Relative Density.	1.068 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (196.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0634 mL	10.3171 mL	20.6343 mL	103.1715 mL
5 mM	0.4127 mL	2.0634 mL	4.1269 mL	20.6343 mL
10 mM	0.2063 mL	1.0317 mL	2.0634 mL	10.3171 mL
20 mM	0.1032 mL	0.5159 mL	1.0317 mL	5.1586 mL
50 mM	0.0413 mL	0.2063 mL	0.4127 mL	2.0634 mL
100 mM	0.0206 mL	0.1032 mL	0.2063 mL	1.0317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc