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CAY10471 Racemate

Name: CAY10471 Racemate
Brand: TargetMol
SKU: T7359
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7359Cas No. 844639-57-2

Alias TM30089 Racemate

CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective CRTH2/DP2 receptor antagonist. It binds to human CRTH2/DP2, DP1, and TP receptors with Ki values of 0.6, 1200, and >10,000 nM, respectively.

CAY10471 Racemate

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Purity: 99.08%

Catalog No. T7359Alias TM30089 RacemateCas No. 844639-57-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$213	In Stock	In Stock
100 mg	$316	In Stock	In Stock
200 mg	$457	-	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.08%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

CAY10471 Racemate AI Summary

CAY10471 Racemate displays a high binding affinity for the human recombinant CRTH2 receptor with a Ki of 6.0 nM and an IC50 value of 3.6 nM, indicating potential activity in modulating allergic responses mediated by this receptor. It also exhibits moderate binding affinity to the prostanoid DP1 receptor with a Ki of 653.0 nM and to the thromboxane receptor with a Ki of 1394.0 nM, while showing low affinity for the TP receptor with a Ki value greater than 10000.0 nM. Additionally, the compound has been shown to inhibit the proliferation of Plasmodium falciparum (DD2) with a potency of 7492.9 nM according to PubChem BioAssay qHTS profiling. Incucyte cell viability assays reveal moderate to high growth rates in U2OS cells, ranging from 0.61 to 0.93, and variable effects on human fibroblast cells, reflecting complex interactions with different cell types. Furthermore, thermal shift assay results indicate diverse effects on the thermal stability of various protein domains, suggesting interactions that may modulate protein function or structure. These bioactivity results support the potential pharmacological interest of CAY10471 Racemate in anti-inflammatory, anti-malarial, and possibly other therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective CRTH2/DP2 receptor antagonist. It binds to human CRTH2/DP2, DP1, and TP receptors with Ki values of 0.6, 1200, and >10,000 nM, respectively.
Targets&IC50	CRTH2:0.6 nM(ki) , DP:1200 nM(ki)
Synonyms	TM30089 Racemate

Chemical Properties

Molecular Weight	416.47
Formula	C₂₁H₂₁FN₂O₄S
Cas No.	844639-57-2
Smiles	[Na+].CN(C1CCc2c(C1)c1ccccc1n2CC([O-])=O)S(=O)(=O)c1ccc(F)cc1
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (360.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4011 mL	12.0057 mL	24.0113 mL	120.0567 mL
5 mM	0.4802 mL	2.4011 mL	4.8023 mL	24.0113 mL
10 mM	0.2401 mL	1.2006 mL	2.4011 mL	12.0057 mL
20 mM	0.1201 mL	0.6003 mL	1.2006 mL	6.0028 mL
50 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4011 mL
100 mM	0.0240 mL	0.1201 mL	0.2401 mL	1.2006 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc