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BI-1206
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Catalog No. T9901A-951 Copy Product Info
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BI-1206 represents a highly specialized antagonistic monoclonal antibody specifically engineered to target the human inhibitory Fc gamma receptor IIB with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of receptor-mediated internalization of therapeutic antibodies across various preclinical experimental models to evaluate the enhancement of antibody-dependent cellular cytotoxicity in specialized oncology research environments.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | BI-1206 represents a highly specialized antagonistic monoclonal antibody specifically engineered to target the human inhibitory Fc gamma receptor IIB with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of receptor-mediated internalization of therapeutic antibodies across various preclinical experimental models to evaluate the enhancement of antibody-dependent cellular cytotoxicity in specialized oncology research environments. |
| In vitro | In ADCP and ADCC assays using mantle cell lymphoma cell lines, BI-1206 blocked FcgammaRIIB-mediated internalization of rituximab, thereby enhancing effector cell-mediated tumor cell killing [1]. |
| In vivo | In human lymphoma xenograft models, systemic administration of BI-1206 in combination with rituximab led to potent tumor regression and significantly improved survival [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Fc-gamma-RIIB/CD32b |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: BI-1206 chemical structure | BI-1206 in vivo | BI-1206 in vitro
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