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BI-1206
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Catalog No. T9901A-951
BI-1206 represents a highly specialized antagonistic monoclonal antibody specifically engineered to target the human inhibitory Fc gamma receptor IIB with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of receptor-mediated internalization of therapeutic antibodies across various preclinical experimental models to evaluate the enhancement of antibody-dependent cellular cytotoxicity in specialized oncology research environments.
BI-1206
BI-1206
Copy Product Info😃Good
Catalog No. T9901A-951
BI-1206 represents a highly specialized antagonistic monoclonal antibody specifically engineered to target the human inhibitory Fc gamma receptor IIB with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of receptor-mediated internalization of therapeutic antibodies across various preclinical experimental models to evaluate the enhancement of antibody-dependent cellular cytotoxicity in specialized oncology research environments.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | BI-1206 represents a highly specialized antagonistic monoclonal antibody specifically engineered to target the human inhibitory Fc gamma receptor IIB with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of receptor-mediated internalization of therapeutic antibodies across various preclinical experimental models to evaluate the enhancement of antibody-dependent cellular cytotoxicity in specialized oncology research environments. |
| In vitro | In ADCP and ADCC assays using mantle cell lymphoma cell lines, BI-1206 blocked FcgammaRIIB-mediated internalization of rituximab, thereby enhancing effector cell-mediated tumor cell killing [1]. |
| In vivo | In human lymphoma xenograft models, systemic administration of BI-1206 in combination with rituximab led to potent tumor regression and significantly improved survival [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Fc-gamma-RIIB/CD32b |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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