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PSB-1491

Name: PSB-1491
Brand: TargetMol
SKU: T24680
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24680Cas No. 1619884-67-1

PSB-1491 is a selective and competitive monoamine oxidase B inhibitor with an IC50 of 0.386 nM, demonstrating over 25,000-fold selectivity compared to MAO-A.

PSB-1491

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Purity: 99.68%

Catalog No. T24680Cas No. 1619884-67-1

PSB-1491 is a selective and competitive monoamine oxidase B inhibitor with an IC50 of 0.386 nM, demonstrating over 25,000-fold selectivity compared to MAO-A.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$108	In Stock	In Stock
10 mg	$162	In Stock	In Stock
25 mg	$268	In Stock	In Stock
50 mg	$392	In Stock	In Stock
100 mg	$668	In Stock	In Stock
500 mg	$2,530	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

PSB-1491 AI Summary

PSB-1491 displays potent inhibitory activity as a selective monoamine oxidase (MAO) inhibitor, particularly targeting MAO-B over MAO-A. It has an IC50 of 1.32 nM for rat recombinant MAO-B and 0.386 nM for human recombinant MAO-B, while exhibiting very weak inhibition of human recombinant MAO-A with an IC50 greater than 10000 nM. The compound also shows strong binding affinity with a Ki value of 0.22 nM for human MAO-B. It demonstrates effective inhibition of other enzymes like AChE and BuChE, enhancing its bioactivity profile in neurotransmitter metabolism modulation. Additionally, PSB-1491 has good kinetic solubility, a favorable distribution coefficient in n-octanol-phosphate buffer, and moderate to high permeability in PAMPA assays, suggesting promising bioavailability and drug-like properties. With a potency index against safinamide greater than 13.0 and a high selectivity ratio (IC50 of 25907 for MAO-B over MAO-A), this compound presents a significant therapeutic potential as an MAO enzyme inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PSB-1491 is a selective and competitive monoamine oxidase B inhibitor with an IC50 of 0.386 nM, demonstrating over 25,000-fold selectivity compared to MAO-A.
Targets&IC50	MAO-B:0.386 nM(human)

Chemical Properties

Molecular Weight	320.17
Formula	C₁₅H₁₁Cl₂N₃O
Cas No.	1619884-67-1
Smiles	CN1C=2C(=CC(C(NC3=CC(Cl)=C(Cl)C=C3)=O)=CC2)C=N1
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (156.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1233 mL	15.6167 mL	31.2334 mL	156.1670 mL
5 mM	0.6247 mL	3.1233 mL	6.2467 mL	31.2334 mL
10 mM	0.3123 mL	1.5617 mL	3.1233 mL	15.6167 mL
20 mM	0.1562 mL	0.7808 mL	1.5617 mL	7.8084 mL
50 mM	0.0625 mL	0.3123 mL	0.6247 mL	3.1233 mL
100 mM	0.0312 mL	0.1562 mL	0.3123 mL	1.5617 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc