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Anti-MMP14 Polyclonal Antibody
😃Good
Catalog No. TMAB-08866
Anti-MMP14 Polyclonal Antibody is a Rabbit antibody targeting MMP14. Anti-MMP14 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-MMP14 Polyclonal Antibody
Anti-MMP14 Polyclonal Antibody
😃Good
Catalog No. TMAB-08866
Anti-MMP14 Polyclonal Antibody is a Rabbit antibody targeting MMP14. Anti-MMP14 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-MMP14 Polyclonal Antibody is a Rabbit antibody targeting MMP14. Anti-MMP14 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Pig,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14. Matrix metalloproteinase-14 precursor is endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. [Catalytic activity] Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain. Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues. Belongs to the peptidase M10A family. |
| Immunogen | KLH conjugated synthetic peptide: human MMP14 |
| Antigen Species | Human |
| Gene Name | MMP14 |
| Gene ID | |
| Protein Name | Matrix metalloproteinase-14 |
| Uniprot ID | |
| Function | Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. |
| Molecular Weight | Theoretical: 54/62 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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