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Bufotalin

Name: Bufotalin
Brand: TargetMol
SKU: T5A2461
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5A2461Cas No. 471-95-4

Alias Bufotaline

1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.

Bufotalin

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Purity: 99.91%

Catalog No. T5A2461Alias BufotalineCas No. 471-95-4

1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$88	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$248	In Stock	In Stock
50 mg	$368	-	In Stock
100 mg	$543	-	In Stock
500 mg	$1,160	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Color:White

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COA HNMR LCMS

Product Introduction

Bufotalin AI Summary

Bufotalin exhibits potent inhibitory activity against primary liver carcinoma (PLC) cell line PLC/PRF/5 with an IC50 value of 0.00034 μg/mL and colchicine-resistant PLC cell line PLC/PRF/5 with an IC50 of 0.0026 μg/mL. It also shows cytotoxic effects on human KB cells with an IC50 of 0.19 μg/mL and on human HL60 cells with an IC50 of less than 0.01 μg/mL, but does not exhibit significant cytotoxicity against mouse MH60 cells (IC50 > 25.0 μg/mL after 72 hours). Additionally, it demonstrates growth inhibition of both IL-6-independent and IL6-dependent mouse MH60 cells with an IC50 of > 56200.0 nM. Bufotalin exhibits cytotoxic activity across various cancer cell lines, including SK-MEL-28, U373, A549, PC3, MCF7, and Hs683, with IC50 values ranging from 9.0 nM to 74.0 nM, indicating its potential as a broad-spectrum anti-cancer agent. Specifically, for human A549 cells, it shows an IC50 of 900.0 nM after 24 hours, and for human HepG2 cells, an IC50 of 500.0 nM after 24 hours. Conversely, it maintains 100.0% cell viability for KM mouse splenic lymphocytes at a 5 μM concentration. These findings suggest that Bufotalin holds significant promise for the development of anti-cancer therapies targeting various human cancers while exhibiting selective cytotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.
Synonyms	Bufotaline

Chemical Properties

Molecular Weight	444.56
Formula	C₂₆H₃₆O₆
Cas No.	471-95-4
Smiles	CC(=O)O[C@H]1C[C@]2(O)[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]2(C)[C@H]1c1ccc(=O)oc1
Relative Density.	1.0942 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (562.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2494 mL	11.2471 mL	22.4942 mL	112.4708 mL
5 mM	0.4499 mL	2.2494 mL	4.4988 mL	22.4942 mL
10 mM	0.2249 mL	1.1247 mL	2.2494 mL	11.2471 mL
20 mM	0.1125 mL	0.5624 mL	1.1247 mL	5.6235 mL
50 mM	0.0450 mL	0.2249 mL	0.4499 mL	2.2494 mL
100 mM	0.0225 mL	0.1125 mL	0.2249 mL	1.1247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc