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Millepachine

Catalog No. T38815 CAS 1393922-01-4

Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Millepachine, CAS 1393922-01-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 328.00
25 mg	In stock	$ 558.00
50 mg	In stock	$ 788.00
100 mg	In stock	$ 1,120.00
1 mL * 10 mM (in DMSO)	In stock	$ 226.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.
Targets&IC50	Proliferation:4 μM(A2780CP cells)
In vitro	Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells. Millepachine (2-8 μM; 24 or 48 h) induces significant G2/M arrest and apoptosis of cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells. The percentage of cells in the G2/M fraction increased from 15.99% in vehicle cells to 24.93%, 60.67%, and 77.31% at dose of 2, 4, and 8 μM in A2780S cells, respectively. Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells. Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells with an IC50 of 4 μM[1].
In vivo	Millepachine (20 mg/kg; i.v.) reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S and A2780CP xenograft models, respectively. Millepachine does not induce acquired drug resistance in an excised A2780S xenograft model[1].

Molecular Weight	350.41
Formula	C22H22O4
CAS No.	1393922-01-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (285.38 mM), Sonication is recommended.

References and Literature

1. Wu W, et, al. Millepachine showed novel antitumor effects in cisplatin-resistant human ovarian cancer through inhibiting drug efflux function of ATP-binding cassette transporters. Phytother Res. 2018 Dec; 32(12):2428-2435.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Compound Library Natural Product Library Natural Product Library for HTS Traditional Chinese Medicine Monomer Library Selected Plant-Sourced Compound Library Bioactive Compound Library Bioactive Compounds Library Max RO5 Drug-like Natural Product Library Anti-Tumor Natural Product Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Millepachine 1393922-01-4 Apoptosis Chinese Millettia bioactive chalcone medicine natural Inhibitor pachycarpa inhibit antitumor herbal Benth cancer inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.