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Cevostamab
(Synonyms: RO7187797, RO 7187797, RG6160, RG 6160, BFCR4350A, BFCR 4350A) Copy Product Info
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Synonyms: RO7187797, RO 7187797, RG6160, RG 6160, BFCR4350A, BFCR 4350A
Catalog No. T76998 Copy Product Info
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Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized bispecific antibody targeting FcRH5/CD3. It binds to FcRH5 expressed on multiple myeloma (MM) cells and CD3 on T cells, promoting T cell synapse formation and inhibiting B-cell malignancies.
Cas No. 2249888-53-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $290 | - | In Stock | |
| 5 mg | $755 | - | In Stock | |
| 10 mg | $1,200 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.1% (SDS-PAGE); 99.6% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized bispecific antibody targeting FcRH5/CD3. It binds to FcRH5 expressed on multiple myeloma (MM) cells and CD3 on T cells, promoting T cell synapse formation and inhibiting B-cell malignancies. |
| In vitro | Cevostamab exhibits potent, dose-dependent killing effects on B cells and bone marrow plasma cells in peripheral blood mononuclear cell (PBMC)/bone marrow monocyte cell (BMMC) samples from rhesus monkeys [1]. |
| In vivo | Cevostamab (0.5 mg/kg; intravenous; weekly) inhibited growth of MOLP-2 tumors in mice reconstituted with human immune cells. |
| Synonyms | RO7187797, RO 7187797, RG6160, RG 6160, BFCR4350A, BFCR 4350A |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal, Bispecific |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD3 & FCRL5/CD307e/FcRH5 |
| Molecular Weight | 146.20 kDa |
| Cas No. | 2249888-53-5 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Cevostamab chemical structure | Cevostamab in vivo | Cevostamab in vitro | Cevostamab molecular weight
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