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Cevostamab (Synonyms: RO7187797, RO 7187797, RG6160, RG 6160, BFCR4350A, BFCR 4350A)

Catalog No. T76998 Copy Product Info
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Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized bispecific antibody targeting FcRH5/CD3. It binds to FcRH5 expressed on multiple myeloma (MM) cells and CD3 on T cells, promoting T cell synapse formation and inhibiting B-cell malignancies.

Cevostamab

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Catalog No. T76998
Synonyms RO7187797, RO 7187797, RG6160, RG 6160, BFCR4350A, BFCR 4350A

Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized bispecific antibody targeting FcRH5/CD3. It binds to FcRH5 expressed on multiple myeloma (MM) cells and CD3 on T cells, promoting T cell synapse formation and inhibiting B-cell malignancies.

Cevostamab
Cas No. 2249888-53-5
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$290-In Stock
5 mg$755-In Stock
10 mg$1,200-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:95.1% (SDS-PAGE); 99.6% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized bispecific antibody targeting FcRH5/CD3. It binds to FcRH5 expressed on multiple myeloma (MM) cells and CD3 on T cells, promoting T cell synapse formation and inhibiting B-cell malignancies.
In vitro
Cevostamab exhibits potent, dose-dependent killing effects on B cells and bone marrow plasma cells in peripheral blood mononuclear cell (PBMC)/bone marrow monocyte cell (BMMC) samples from rhesus monkeys [1].
In vivo
Cevostamab (0.5 mg/kg; intravenous; weekly) inhibited growth of MOLP-2 tumors in mice reconstituted with human immune cells.
SynonymsRO7187797, RO 7187797, RG6160, RG 6160, BFCR4350A, BFCR 4350A
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal, Bispecific
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetCD3 & FCRL5/CD307e/FcRH5
Chemical Properties
Molecular Weight146.20 kDa
Cas No.2249888-53-5
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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