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Myriocin
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Catalog No. T16165Cas No. 35891-70-4
Alias Thermozymocidin, ISP-I
Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour growth by regulating macrophage polarisation and function through the PI3K/Akt/mTOR pathway.Myriocin inhibits HCV infection and can be used in the study of neurological diseases. Myriocin inhibits HCV infection and can be used to study neuropathy and fungal infections.
Myriocin
Copy Product Info😃Good
Catalog No. T16165Alias Thermozymocidin, ISP-ICas No. 35891-70-4
Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour growth by regulating macrophage polarisation and function through the PI3K/Akt/mTOR pathway.Myriocin inhibits HCV infection and can be used in the study of neurological diseases. Myriocin inhibits HCV infection and can be used to study neuropathy and fungal infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $199 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:>99.99%
Appearance:Solid
Color:White
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Product Introduction
Myriocin AI Summary
Myriocin demonstrates a range of potent bioactivities, particularly its immunosuppressive capabilities with an IC50 value of 3.0 nM in inhibiting mouse allogenic mixed leukocyte response. In vivo studies show it significantly prolongs the mean survival time (MST) of rat skin allografts in a dose-dependent manner, achieving an MST of up to 11.2 days at the highest dose of 0.3 mg/kg. Additionally, it displays antimicrobial activity against several plant pathogens, including Botrytis cinerea and Fusarium oxysporum. Myriocin also inhibits serine palmitoyltransferase and squalene synthase, affecting membrane lipid composition and enzyme phosphorylation levels. Its inhibitory effects extend to fructose-1,6-bisphosphate aldolase from Giardia Lamblia, human tyrosyl-DNA phosphodiesterase 1, and protein binding in plasma. Further evaluation indicates its potential in cancer therapy by inhibiting cell viability in cancer cell lines and targeting SPT-related pathways. However, it exhibits toxicity in rats at higher concentrations, necessitating cautious therapeutic development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour growth by regulating macrophage polarisation and function through the PI3K/Akt/mTOR pathway.Myriocin inhibits HCV infection and can be used in the study of neurological diseases. Myriocin inhibits HCV infection and can be used to study neuropathy and fungal infections. |
| Synonyms | Thermozymocidin, ISP-I |
| Molecular Weight | 401.54 |
| Formula | C21H39NO6 |
| Cas No. | 35891-70-4 |
| Smiles | CCCCCCC(=O)CCCCCC\C=C\C[C@@H](O)[C@H](O)[C@@](N)(CO)C(O)=O |
| Relative Density. | 1.123g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.49 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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