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ML355

🥰Excellent

Catalog No. T4347Cas No. 1532593-30-8

ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.

ML355

🥰Excellent

Purity: 98.2%

Catalog No. T4347Cas No. 1532593-30-8

ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.

Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$313	In Stock
50 mg	$513	In Stock
100 mg	$787	In Stock
200 mg	$1,070	In Stock
1 mL x 10 mM (in DMSO)	$103	In Stock

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Batch Information

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Purity:98.2%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
Targets&IC50	12-LOX:0.34 μM

Chemical Properties

Molecular Weight	441.52
Formula	C₂₁H₁₉N₃O₄S₂
Cas No.	1532593-30-8
Smiles	COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nc3ccccc3s2)c1O
Relative Density.	1.481 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (124.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2649 mL	11.3245 mL	22.6490 mL	113.2452 mL
5 mM	0.4530 mL	2.2649 mL	4.5298 mL	22.6490 mL
10 mM	0.2265 mL	1.1325 mL	2.2649 mL	11.3245 mL
20 mM	0.1132 mL	0.5662 mL	1.1325 mL	5.6623 mL
50 mM	0.0453 mL	0.2265 mL	0.4530 mL	2.2649 mL
100 mM	0.0226 mL	0.1132 mL	0.2265 mL	1.1325 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc