Shopping Cart

Your shopping cart is currently empty

SKF 81297 hydrobromide

Name: SKF 81297 hydrobromide
Brand: TargetMol
SKU: T23361
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T23361Cas No. 67287-39-2

Alias SKF81297 hydrobromide

SKF 81297 hydrobromide is a selective agonist of the dopamine D1-like receptor, with a high affinity for both D1 and D5 subtypes (Ki = 1.9 nM). SKF 81297 hydrochloride exhibits central activity in vivo and is widely used to study the neuromodulatory effects of the dopamine system, particularly in studies related to cognitive function and motor activity, such as Parkinson's disease.

SKF 81297 hydrobromide

😃Good

Purity: 99.52%

Catalog No. T23361Alias SKF81297 hydrobromideCas No. 67287-39-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$322	In Stock	In Stock
100 mg	$483	-	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.52%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SKF 81297 hydrobromide is a selective agonist of the dopamine D1-like receptor, with a high affinity for both D1 and D5 subtypes (Ki = 1.9 nM). SKF 81297 hydrochloride exhibits central activity in vivo and is widely used to study the neuromodulatory effects of the dopamine system, particularly in studies related to cognitive function and motor activity, such as Parkinson's disease.
In vivo	SKF 81297 hydrobromide (0.05-0.3 mg/kg, intramuscularly) can stimulate MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to impair motor behavior in monkeys. [1]
Synonyms	SKF81297 hydrobromide

Chemical Properties

Molecular Weight	370.67
Formula	C₁₆H₁₇BrClNO₂
Cas No.	67287-39-2
Smiles	Br.ClC=1C(O)=C(O)C=C2C1CCNCC2C=3C=CC=CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 1 mg/mL (2.7 mM), Sonication is recommended.

DMF: 20 mg/mL (53.96 mM), Sonication is recommended.

DMSO: 20 mg/mL (53.96 mM), Sonication is recommended.

In Vivo Formulation

Saline: 2 mg/mL (5.4 mM), Suspension.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6978 mL	13.4891 mL	26.9782 mL	134.8909 mL

DMF/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5396 mL	2.6978 mL	5.3956 mL	26.9782 mL
10 mM	0.2698 mL	1.3489 mL	2.6978 mL	13.4891 mL
20 mM	0.1349 mL	0.6745 mL	1.3489 mL	6.7445 mL
50 mM	0.0540 mL	0.2698 mL	0.5396 mL	2.6978 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc