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Antibiofilm agent-18

Name: Antibiofilm agent-18
Brand: TargetMol
SKU: T214799
Rating: 4.5 (1 reviews)

Catalog No. T214799 Copy Product Info

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Antibiofilm agent-18 is a tetrahydropyridine derivative that acts to inhibit biofilm formation. It effectively disrupts the biofilms of Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) and exhibits low cytotoxicity. Antibiofilm agent-18 is applicable in research related to bacterial infections.

Antibiofilm agent-18

Copy Product Info

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Catalog No. T214799

Antibiofilm agent-18

Cas No. 1989688-84-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

In vitro

Antibiofilm agent-18, also known as Compound 4I, effectively disrupts the biofilms of Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) in a dose-dependent manner at concentrations of 5-15 μg/mL over 24 hours. At a concentration of 100 μg/mL for 24-48 hours, this compound shows low cytotoxicity in AGS cells. Additionally, Antibiofilm agent-18 exhibits high-affinity binding to various biofilm-associated proteins, including sarA, crtM, fnbA, PBP2, clfA, clfB, AgrA, and Agrc.

Chemical Properties

Molecular Weight	571.54
Formula	C₃₄H₃₂Cl₂N₂O₂
Cas No.	1989688-84-7
Smiles	C(OCC)(=O)C=1[C@H](N([C@@H](CC1NC2=CC=C(Cl)C=C2)C3=CC=C(C)C=C3)C4=CC=C(Cl)C=C4)C5=CC=C(C)C=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc