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TSI-01

🥰Excellent
Catalog No. T24904Cas No. 704878-75-1
Alias TSI01, TSI 01

TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 μM and 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.

TSI-01

TSI-01

🥰Excellent
Purity: 99.87%
Catalog No. T24904Alias TSI01, TSI 01Cas No. 704878-75-1
TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 μM and 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.
Pack SizePriceAvailabilityQuantity
1 mg$74In Stock
5 mg$179In Stock
10 mg$313In Stock
25 mg$687In Stock
50 mg$1,090In Stock
100 mg$1,730In Stock
200 mg$2,330In Stock
1 mL x 10 mM (in DMSO)$198In Stock
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Purity:99.87%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 μM and 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.
SynonymsTSI01, TSI 01
Chemical Properties
Molecular Weight328.15
FormulaC14H11Cl2NO4
Cas No.704878-75-1
SmilesO=C(OC(C)C)C1=CC=C(C=C1)N2C(=O)C(Cl)=C(Cl)C2=O
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (304.74 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0474 mL15.2369 mL30.4739 mL152.3693 mL
5 mM0.6095 mL3.0474 mL6.0948 mL30.4739 mL
10 mM0.3047 mL1.5237 mL3.0474 mL15.2369 mL
20 mM0.1524 mL0.7618 mL1.5237 mL7.6185 mL
50 mM0.0609 mL0.3047 mL0.6095 mL3.0474 mL
100 mM0.0305 mL0.1524 mL0.3047 mL1.5237 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

TSI-01
Related Tags: buy TSI-01 | purchase TSI-01 | TSI-01 cost | order TSI-01 | TSI-01 chemical structure | TSI-01 formula | TSI-01 molecular weight
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