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Ceftaroline hydrochloride

Name: Ceftaroline hydrochloride
Brand: TargetMol
SKU: T37966L
Price: 398 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: T-91825 HCl, PPI-0903M HCl, Ceftaroline HCl (189345-04-8 Free base)) Copy Product Info

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Synonyms: T-91825 HCl, PPI-0903M HCl, Ceftaroline HCl (189345-04-8 Free base)

Catalog No. T37966L Copy Product Info

Purity: 99.25%

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Ceftaroline hydrochloride (T-91825 HCl, PPI-0903M HCl) is an N-phosphorylated cephalosporin antibiotic and the active form released upon dephosphorylation of the prodrug TAK-599 (ceftaroline fosamil) after it enters the body. Its mechanism of action involves high affinity for penicillin-binding protein 2a (PBP2a), which is associated with methicillin-resistant Staphylococcus aureus (MRSA) resistance (IC50 = 0.90 μg/mL). Ceftaroline hydrochloride kills various Gram-positive and Gram-negative bacteria by blocking bacterial cell wall synthesis, including resistant strains such as MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE), and Streptococcus pneumoniae.

Cas No. 614758-10-0

Pack Size	Price	USA Stock	Global Stock
1 mg	$398	-	In Stock
5 mg	$876	-	In Stock
10 mg	$1,310	-	In Stock
25 mg	$2,230	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.25%

ee:100%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS CSFC

Product Introduction

Bioactivity

Description	Ceftaroline hydrochloride (T-91825 HCl, PPI-0903M HCl) is an N-phosphorylated cephalosporin antibiotic and the active form released upon dephosphorylation of the prodrug TAK-599 (ceftaroline fosamil) after it enters the body. Its mechanism of action involves high affinity for penicillin-binding protein 2a (PBP2a), which is associated with methicillin-resistant Staphylococcus aureus (MRSA) resistance (IC50 = 0.90 μg/mL). Ceftaroline hydrochloride kills various Gram-positive and Gram-negative bacteria by blocking bacterial cell wall synthesis, including resistant strains such as MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE), and Streptococcus pneumoniae.
In vitro	Ceftaroline hydrochloride is effective against S. aureus infections (MIC50 = 0.25 μg/mL), including MRSA (MIC50 = 1 μg/mL)[1]. Ceftaroline hydrochloride is effective against S. aureus, an intermediate for heteromycin, with MIC50s ranging from 0.25 to 4 μg/mL [1].
Synonyms	T-91825 HCl, PPI-0903M HCl, Ceftaroline HCl (189345-04-8 Free base)

Chemical Properties

Molecular Weight	677.63
Formula	C₂₂H₂₂Cl₂N₈O₅S₄
Cas No.	614758-10-0
Smiles	C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OCC)/C3=NSC(N)=N3)=O)C2=O)(SCC1SC4=NC(=CS4)C=5C=C[N+](C)=CC5)[H].[Cl-].Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Ceftaroline hydrochloride chemical structure | Ceftaroline hydrochloride in vitro | Ceftaroline hydrochloride formula | Ceftaroline hydrochloride molecular weight