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Olodaterol hydrochloride

Name: Olodaterol hydrochloride
Brand: TargetMol
SKU: T5159
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5159Cas No. 869477-96-3

Alias BI-1744 HCl, BI 1744 hydrochloride

Olodaterol hydrochloride (BI-1744 HCl) is a novel, long-acting β2-adrenergic agonist (EC50s: 97.7 nM for the human β2-adrenoceptor) that exerts its pharmacological effect by binding and activating β2-adrenergic receptors.

Olodaterol hydrochloride

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Purity: 99.11%

Catalog No. T5159Alias BI-1744 HCl, BI 1744 hydrochlorideCas No. 869477-96-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$143	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$745	-	In Stock
200 mg	$987	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.11%

Appearance:Viscous

Color:Yellow

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COA HNMR LCMS

Product Introduction

Olodaterol hydrochloride AI Summary

Olodaterol hydrochloride exhibits potent agonist activity at the human beta2 adrenoreceptor with an EC50 value of 0.008511 nM, indicating high affinity for this receptor. It demonstrates partial agonist activity at the same receptor with an activity level of 30.6%. The compound shows selectivity towards the beta2 adrenoreceptor over the beta1 adrenoreceptor with a Selectivity Index of 3.51. In Dunkin-Hartley guinea pig trachea, Olodaterol hydrochloride significantly reduces histamine-induced muscle contraction, acting as an agonist at the beta2 adrenergic receptor, with variations in Emax and onset time of action..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Olodaterol hydrochloride (BI-1744 HCl) is a novel, long-acting β2-adrenergic agonist (EC50s: 97.7 nM for the human β2-adrenoceptor) that exerts its pharmacological effect by binding and activating β2-adrenergic receptors.
Targets&IC50	β2-adrenoceptor (human):97.7 nM(EC50)
Synonyms	BI-1744 HCl, BI 1744 hydrochloride

Chemical Properties

Molecular Weight	422.9
Formula	C₂₁H₂₇ClN₂O₅
Cas No.	869477-96-3
Smiles	Cl.COc1ccc(CC(C)(C)NC[C@H](O)c2cc(O)cc3NC(=O)COc23)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (141.88 mM), Sonication is recommended.

H2O: 15 mg/mL (35.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3646 mL	11.8231 mL	23.6463 mL	118.2313 mL
5 mM	0.4729 mL	2.3646 mL	4.7293 mL	23.6463 mL
10 mM	0.2365 mL	1.1823 mL	2.3646 mL	11.8231 mL
20 mM	0.1182 mL	0.5912 mL	1.1823 mL	5.9116 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0473 mL	0.2365 mL	0.4729 mL	2.3646 mL
100 mM	0.0236 mL	0.1182 mL	0.2365 mL	1.1823 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc