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GSK2292767

Name: GSK2292767
Brand: TargetMol
SKU: T6850
Rating: 4.5 (1 reviews)

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Catalog No. T6850Cas No. 1254036-66-2

GSK2292767 is a potent and selective inhibitor of PI3Kδ.

GSK2292767

😃Good

Catalog No. T6850Cas No. 1254036-66-2

GSK2292767 is a potent and selective inhibitor of PI3Kδ.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$159	35 days	35 days
5 mg	$716	35 days	35 days
10 mg	$1,280	35 days	35 days
25 mg	$2,880	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	GSK2292767 is a potent and selective inhibitor of PI3Kδ.
Targets&IC50	PI3Kδ:10.1 (pIC50)
In vitro	BI-847325 shows growth-inhibitory effects on BRAF-mutant and vemurafenib-resistant melanoma cells with IC50 ranging from 0.3 nM to 2 μM, and prevents colony formation in six BRAF-mutant melanoma cell lines. BI-847325 also induces apoptosis by reducing Mcl-1 expression. [1]
In vivo	GSK2292767 is highly selective for PI3Kδ over the closely related isoforms and is active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation[1].

Chemical Properties

Molecular Weight	512.58
Formula	C₂₄H₂₈N₆O₅S
Cas No.	1254036-66-2
Smiles	C(C=1OC(C2=C3C(=CC(=C2)C=4C=C(NS(C)(=O)=O)C(OC)=NC4)NN=C3)=NC1)N5C[C@H](C)O[C@H](C)C5
Relative Density.	1.360 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 93 mg/mL (181.44 mM), Sonication is recommended.

Ethanol: <1 mg/mL

H2O: <1 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9509 mL	9.7546 mL	19.5091 mL	97.5457 mL
5 mM	0.3902 mL	1.9509 mL	3.9018 mL	19.5091 mL
10 mM	0.1951 mL	0.9755 mL	1.9509 mL	9.7546 mL
20 mM	0.0975 mL	0.4877 mL	0.9755 mL	4.8773 mL
50 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9509 mL
100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.9755 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc