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Anti-IRS1 Polyclonal Antibody

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Catalog No. TMAB-00988

Anti-IRS1 Polyclonal Antibody is a Rabbit antibody targeting IRS1. Anti-IRS1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-IRS1 Polyclonal Antibody

Anti-IRS1 Polyclonal Antibody

😃Good
Catalog No. TMAB-00988
Anti-IRS1 Polyclonal Antibody is a Rabbit antibody targeting IRS1. Anti-IRS1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3737-10 days
200 μL$5297-10 days
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Product Introduction

Bioactivity
Description
Anti-IRS1 Polyclonal Antibody is a Rabbit antibody targeting IRS1. Anti-IRS1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Mouse,Rat (predicted:Human,Pig,Cow,Horse,Rabbit,Sheep)
Verified Activity
1. Paraformaldehyde-fixed, paraffin embedded Rat Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining.
3. Paraformaldehyde-fixed, paraffin embedded Mouse Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining.
Application
IHC-P,IHC-Fr,IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-300
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationIRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundInsulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: rat IRS-1
Antigen Species
Rat
Gene ID
Uniprot ID
Biology Area
Tumor Associated,Insulin / Insulin-like,Cytoplasmic,Metabolism,Obesity,Heart disease,Diabetes,Cancer,Diabetes associated,Signal transduction
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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