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Anti-IRS1 Polyclonal Antibody
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Catalog No. TMAB-00988
Alias IRS-1, Insulin receptor substrate 1
Anti-IRS1 Polyclonal Antibody is a Rabbit antibody targeting IRS1. Anti-IRS1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-IRS1 Polyclonal Antibody
Anti-IRS1 Polyclonal Antibody
😃Good
Catalog No. TMAB-00988Alias IRS-1, Insulin receptor substrate 1
Anti-IRS1 Polyclonal Antibody is a Rabbit antibody targeting IRS1. Anti-IRS1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $529 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-IRS1 Polyclonal Antibody is a Rabbit antibody targeting IRS1. Anti-IRS1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Alias | IRS-1, Insulin receptor substrate 1 |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Pig,Cow,Horse,Rabbit,Sheep) |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded Rat Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded Mouse Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-300 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | IRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed. |
| Immunogen | KLH conjugated synthetic peptide: rat IRS-1 |
| Antigen Species | Rat |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Tumor Associated,Insulin / Insulin-like,Cytoplasmic,Metabolism,Obesity,Heart disease,Diabetes,Cancer,Diabetes associated,Signal transduction |
| Molecular Weight | Theoretical: 137 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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