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USP15-IN-1

USP15-IN-1
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Purity:99.81%
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USP15-IN-1

Catalog No. T61575Cas No. 2260826-16-0
USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM). USP15-IN-1 showed high antiproliferative activity against non-small cell lung cancer and leukemia cells. USP15 is an interacting protein of cGAS, and USP15 can promote cGAS to recognize DNA and activate downstream signaling pathways.
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Pack SizePriceAvailabilityQuantity
1 mg$128In Stock
5 mg$322In Stock
10 mg$511In Stock
25 mg$829In Stock
50 mg$1,150In Stock
100 mg$1,550In Stock
500 mg$2,970In Stock
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Product Introduction

Bioactivity
Description
USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM). USP15-IN-1 showed high antiproliferative activity against non-small cell lung cancer and leukemia cells. USP15 is an interacting protein of cGAS, and USP15 can promote cGAS to recognize DNA and activate downstream signaling pathways.
In vitro
USP15-IN-1 (0.001-5 μM; 48 h) demonstrates significant inhibitory effects on the proliferation of non-small cell lung carcinoma and leukemia cells, as reported in.[1]
Chemical Properties
Molecular Weight377.44
FormulaC22H23N3O3
Cas No.2260826-16-0
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 90.0 mg/mL (238.4 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6494 mL13.2471 mL26.4943 mL132.4714 mL
5 mM0.5299 mL2.6494 mL5.2989 mL26.4943 mL
10 mM0.2649 mL1.3247 mL2.6494 mL13.2471 mL
20 mM0.1325 mL0.6624 mL1.3247 mL6.6236 mL
50 mM0.0530 mL0.2649 mL0.5299 mL2.6494 mL
100 mM0.0265 mL0.1325 mL0.2649 mL1.3247 mL

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