Shopping Cart

Your shopping cart is currently empty

JG26

Name: JG26
Brand: TargetMol
SKU: T27654
Price: 523 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T27654Cas No. 1464910-32-4

Alias JG-26, JG 26

JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.

JG26

Copy Product Info

😃Good

Purity: 99.08%

Catalog No. T27654Alias JG-26, JG 26Cas No. 1464910-32-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$83	-	In Stock
5 mg	$198	-	In Stock
10 mg	$297	-	In Stock
25 mg	$523	-	In Stock
50 mg	Preferential	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.08%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

JG26 AI Summary

JG26 exhibits bioactivity as a potent inhibitor of ADAM-17, with IC50 values ranging from 1.9 nM to 4272.0 nM across different cell lines and induction methods. It demonstrates high selectivity for ADAM-17 over other metalloproteinases like MMP-14, MMP-9, and MMP-2, with selectivity ratios in IC50 values ranging from 126.0 to 10000.0. The compound also shows inhibitory activity against recombinant ADAM-10 (IC50 of 150.0 nM) and recombinant ADAM-8 (IC50 of 12.0 nM), and it inhibits the shedding of CD23 by ADAM-8 with an IC50 of 120.0 nM. Additionally, it inhibits MMP-1 in human rheumatoid synovial fibroblasts with an IC50 greater than 500000.0 nM, as well as MMP-2 (IC50 of 240.0 nM), MMP-9 (IC50 of 1630.0 nM), MMP-12 (IC50 of 9.4 nM), and MMP-14 catalytic domain (IC50 of 19500.0 nM). Furthermore, the compound exhibits a 59.87% activity in inhibiting cell invasion in human MDA-MB-231 cells as assessed using DAPI staining based confocal microscopy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.
Targets&IC50	ADAM17:1.9 nM (IC50), MMP8:240 nM (IC50), MMP14:19500 nM (IC50), MMP12:9.4 nM (IC50), ADAM10:150 nM (IC50), MMP9:>500000 nM (IC50), MMP9:1630 nM (IC50), ADAM8:12 nM (IC50)
Synonyms	JG-26, JG 26

Chemical Properties

Molecular Weight	594.27
Formula	C₁₉H₂₂Br₂N₄O₆S
Cas No.	1464910-32-4
Smiles	S(N[C@H](CCCNC(N)=O)C(NO)=O)(=O)(=O)C1=CC=C(OCC2=CC(Br)=CC(Br)=C2)C=C1
Relative Density.	1.683 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (84.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6827 mL	8.4137 mL	16.8274 mL	84.1368 mL
5 mM	0.3365 mL	1.6827 mL	3.3655 mL	16.8274 mL
10 mM	0.1683 mL	0.8414 mL	1.6827 mL	8.4137 mL
20 mM	0.0841 mL	0.4207 mL	0.8414 mL	4.2068 mL
50 mM	0.0337 mL	0.1683 mL	0.3365 mL	1.6827 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc