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JG26

Name: JG26
Brand: TargetMol
SKU: T27654
Price: 523 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T27654Cas No. 1464910-32-4

Alias JG-26, JG 26

JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.

JG26

🥰Excellent

Purity: 99.08%

Catalog No. T27654Alias JG-26, JG 26Cas No. 1464910-32-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$83	-	In Stock
5 mg	$198	-	In Stock
10 mg	$297	-	In Stock
25 mg	$523	-	In Stock
50 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.08%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.
Targets&IC50	MMP8:240 nM (IC50), MMP14:19500 nM (IC50), ADAM8:12 nM (IC50), ADAM17:1.9 nM (IC50), MMP9:1630 nM (IC50), ADAM10:150 nM (IC50), MMP12:9.4 nM (IC50), MMP9:>500000 nM (IC50)
Synonyms	JG-26, JG 26

Chemical Properties

Molecular Weight	594.27
Formula	C₁₉H₂₂Br₂N₄O₆S
Cas No.	1464910-32-4
Smiles	S(N[C@H](CCCNC(N)=O)C(NO)=O)(=O)(=O)C1=CC=C(OCC2=CC(Br)=CC(Br)=C2)C=C1
Relative Density.	1.683 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (84.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6827 mL	8.4137 mL	16.8274 mL	84.1368 mL
5 mM	0.3365 mL	1.6827 mL	3.3655 mL	16.8274 mL
10 mM	0.1683 mL	0.8414 mL	1.6827 mL	8.4137 mL
20 mM	0.0841 mL	0.4207 mL	0.8414 mL	4.2068 mL
50 mM	0.0337 mL	0.1683 mL	0.3365 mL	1.6827 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc