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Ipragliflozin

Name: Ipragliflozin
Brand: TargetMol
SKU: T2385
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2385Cas No. 761423-87-4

Alias ASP1941

Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.

Ipragliflozin

🥰Excellent

Purity: 99.70%

Catalog No. T2385Alias ASP1941Cas No. 761423-87-4

Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.

Pack Size	Price	Availability
25 mg	$52	In Stock
50 mg	$84	In Stock
100 mg	$137	In Stock
200 mg	$218	In Stock
500 mg	$462	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Purity:99.70%

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COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.
Targets&IC50	SGLT2 (rat):6.73 nM, SGLT2 (human):7.4 nM, SGLT2:5.64 nM, SGLT1 (rat):1166 nM, SGLT1 (mouse):1380 nM, SGLT1 (human):1876 nM
Kinase Assay	Inhibition of TNF-α synthesis: TNF-α inhibitory activity is measured in lipopolysacharide (LPS) stimulated PBMC. Pomalidomide is added to human PBMCs 1 hour prior to the addition of LPS (1 μg/mL) and incubation continued for an additional 18-20 hours. Supernatants are then harvested, and the concentration of TNF-α in the supernatants is determined by ELISA. The concentration of Pomalidomide that inhibits TNF- production by 50% (IC50) is calculated by nonlinear regression analysis. The human whole blood TNF- inhibition assay is run in a similar fashion to the PBMC assay except that heparinized fresh human whole blood is plated directly into microtiter plates.
Synonyms	ASP1941

Chemical Properties

Molecular Weight	404.45
Formula	C₂₁H₂₁FO₅S
Cas No.	761423-87-4
Smiles	O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC3=CC=4C(S3)=CC=CC4)=C(F)C=C2
Relative Density.	1.452 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (173.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4725 mL	12.3625 mL	24.7249 mL	123.6247 mL
5 mM	0.4945 mL	2.4725 mL	4.9450 mL	24.7249 mL
10 mM	0.2472 mL	1.2362 mL	2.4725 mL	12.3625 mL
20 mM	0.1236 mL	0.6181 mL	1.2362 mL	6.1812 mL
50 mM	0.0494 mL	0.2472 mL	0.4945 mL	2.4725 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc