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Anti-ASGR1 Polyclonal Antibody
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Catalog No. TMAB-00153
Alias HL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR
Anti-ASGR1 Polyclonal Antibody is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Polyclonal Antibody can be used in WB.
Anti-ASGR1 Polyclonal Antibody
Anti-ASGR1 Polyclonal Antibody
😃Good
Catalog No. TMAB-00153Alias HL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR
Anti-ASGR1 Polyclonal Antibody is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $529 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ASGR1 Polyclonal Antibody is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Polyclonal Antibody can be used in WB. |
| Synonyms | HL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Pig,Cow,Horse,Rabbit) |
| Verified Activity | Sample: Lane 1: Rat Liver tissue lysates Lane 2: Human HepG2 cell lysates Primary: Anti-ASGPR1 (TMAB-00153) at 1/200 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kDa Observed band size: 47 kDa  |
| Application | |
| Recommended Dose | WB: 1:200-1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | ASGR is a heterooligomeric receptor that is abundantly expressed on the sinusoidal surface of the hepatic plasma membrane. It is an endocytic receptor that rapidly binds and internalizes galactose-terminated glycoproteins (asialoglycoproteins or ASGP) from the circulation. The mouse ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The aa sequence of mouse ASGPR1 ECD is 89% and 79% identical to the ASGPR1 ECD of rat and human, respectively. |
| Immunogen | KLH conjugated synthetic peptide: human ASGPR1 |
| Antigen Species | Human |
| Gene Name | ASGR1 |
| Gene ID | |
| Protein Name | Asialoglycoprotein receptor 1 |
| Uniprot ID | |
| Biology Area | Organelle Proteins |
| Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| Molecular Weight | Theoretical: 32 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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