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Pyrazinamide

Name: Pyrazinamide
Brand: TargetMol
SKU: T1426
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1426Cas No. 98-96-4

Alias Pyrazinoic acid amide, Pyrazinecarboxamide

Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.

Pyrazinamide

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Purity: 99.95%

Catalog No. T1426Alias Pyrazinoic acid amide, PyrazinecarboxamideCas No. 98-96-4

Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$31	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Pyrazinamide AI Summary

Pyrazinamide exhibits potent antimycobacterial activity against Mycobacterium tuberculosis H37Rv, with a minimum inhibitory concentration (MIC) ranging from 3.125 to 50.0 ug/mL depending on the assay method and conditions used. The compound has demonstrated varying efficacy across different media and pH levels, with its strongest activity recorded at 3.125 ug/mL using the microplate alamar blue assay. Additionally, Pyrazinamide shows some efficacy against multidrug-resistant Mycobacterium tuberculosis strains with MIC values up to 128.0 ug/mL. The compound also exhibits pharmacokinetic properties such as a half-life (T1/2) of approximately 6.6 to 6.9 hours and high plasma protein binding (>91%), indicating significant bioavailability and distribution in mammalian systems. While showing strong antimycobacterial activity, Pyrazinamide displays moderate to low cytotoxicity, as noted in HepG2 and Vero cells assays. These bioactivities suggest its potential as a candidate for further development in antitubercular drug research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.
Synonyms	Pyrazinoic acid amide, Pyrazinecarboxamide

Chemical Properties

Molecular Weight	123.11
Formula	C₅H₅N₃O
Cas No.	98-96-4
Smiles	NC(=O)C1=NC=CN=C1
Relative Density.	1.3260 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 2 mg/mL (16.25 mM), Sonication is recommended.

DMSO: 20 mg/mL (162.46 mM), Sonication is recommended.

H2O: 10 mg/mL (81.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (16.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	8.1228 mL	40.6141 mL	81.2282 mL	406.1408 mL
5 mM	1.6246 mL	8.1228 mL	16.2456 mL	81.2282 mL
10 mM	0.8123 mL	4.0614 mL	8.1228 mL	40.6141 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.4061 mL	2.0307 mL	4.0614 mL	20.3070 mL
50 mM	0.1625 mL	0.8123 mL	1.6246 mL	8.1228 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0812 mL	0.4061 mL	0.8123 mL	4.0614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc