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(RS)-(Tetrazol-5-yl)glycine

Name: (RS)-(Tetrazol-5-yl)glycine
Brand: TargetMol
SKU: T16801
Rating: 4.5 (1 reviews)

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Catalog No. T16801Cas No. 138199-51-6

Alias LY 285265, D,L-(tetrazol-5-yl)glycine

(RS)-(Tetrazol-5-yl)glycine is a potent and selective N-methyl-D-aspartate (NMDA) receptor agonist that can induce seizure models and Fos expression in mice. Its EC50 values for GluN1/GluN2D and GluN1/GluN2A are 99 nM and 1.7 μM, respectively.

(RS)-(Tetrazol-5-yl)glycine

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Catalog No. T16801Alias LY 285265, D,L-(tetrazol-5-yl)glycineCas No. 138199-51-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	Inquiry	Inquiry
25 mg	$86	Inquiry	Inquiry
50 mg	$148	Inquiry	Inquiry
100 mg	$212	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	(RS)-(Tetrazol-5-yl)glycine is a potent and selective N-methyl-D-aspartate (NMDA) receptor agonist that can induce seizure models and Fos expression in mice. Its EC50 values for GluN1/GluN2D and GluN1/GluN2A are 99 nM and 1.7 μM, respectively.
Targets&IC50	GluN1/GluN2D:(EC50)99 nM, GluN1/GluN2A:1.7 μM(EC50)
In vitro	(RS)-(Tetrazol-5-yl)glycine does not significantly inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). It displaces NMDA receptor binding to rat brain membranes using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1].
In vivo	(RS)-(Tetrazol-5-yl)glycine is a potent convulsant in neonatal rats (ED50=0.071 mg/kg; i.p.) and induces seizure responses and Fos in NR1+/+ and NR1-/- mice (1.25, 1.5 mg/kg; IP) [1][3].
Synonyms	LY 285265, D,L-(tetrazol-5-yl)glycine

Chemical Properties

Molecular Weight	143.1
Formula	C₃H₅N₅O₂
Cas No.	138199-51-6
Smiles	NC(C(O)=O)c1nn[nH]n1
Relative Density.	1.804 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1.43 mg/mL (10 mM, insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9881 mL	34.9406 mL	69.8812 mL	349.4060 mL
5 mM	1.3976 mL	6.9881 mL	13.9762 mL	69.8812 mL
10 mM	0.6988 mL	3.4941 mL	6.9881 mL	34.9406 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc