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Anti-USP7 Antibody (5F63)
😃Good
Catalog No. TMAY-01987
Alias ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP
Anti-USP7 Antibody (5F63) is a Mouse antibody targeting USP7. Anti-USP7 Antibody (5F63) can be used in ELISA.
Anti-USP7 Antibody (5F63)
Anti-USP7 Antibody (5F63)
😃Good
Catalog No. TMAY-01987Alias ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP
Anti-USP7 Antibody (5F63) is a Mouse antibody targeting USP7. Anti-USP7 Antibody (5F63) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-USP7 Antibody (5F63) is a Mouse antibody targeting USP7. Anti-USP7 Antibody (5F63) can be used in ELISA. |
| Alias | ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 5F63 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human USP7 / HAUSP (rh USP7 / HAUSP; TMPY-01463; Lys 208-Glu 560; NP_003461.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein that belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP stimulates lytic infection and the reactivation of quiescent viral genomes. ICP interacts very strongly with USP7. USP7-mediated stabilization of ICP is dominant over ICP-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP are expressed. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human USP7 / HAUSP Protein (TMPY-01463) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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