Adenosine Deaminase

8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

EHNA hydrochloride is a selective inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA) with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner. EHNA hydrochloride inhibits PHA and NaI04 mitogenesis.

Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.

Pentostatin (CI-825) is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).

AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, useful for studying anorexia in the nervous system.

Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.

3'-O-Methyladenosine is an antiviral compound with inhibitory activity against West Nile Virus and can be used for the treatment of viral infections.3'-O-Methyladenosine inhibits adenosine deaminase type VII with a Ki value of 493 µM.

Erdosteine (RV 144) is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus production and viscosity, by which facilitating mucociliary transport and improving expectoration. This agent also suppresses the chemical-induced cough reflex as well as protects lung tissues from damages caused by cigarette smoking mediated through free radicals scavenging.

Bupirimate (Nimrod), an active ingredient in plant protection products, is commonly used as a systemic fungicide and finds applications in controlling powdery mildew in roses, apple plantations. It belongs to the family of pyrimidines.

1-Deazaadenosine, a potent Adenosine deaminase inhibitor (Ki: 0.66 μM), exhibits anti-cancer activities in vitro and holds potential as a chemotherapy agent for lymphoproliferative disorders.

Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of 2'-deoxyadenosine and adenosine to 2'-deoxyinosine and inosine, respectively.

2-Hydroxy-3′-O-methyladenosine serves as a synthetic intermediate in the study of ischemic heart disease, cerebrovascular disease, kidney disease, inflammatory allergies, and more. Derived from 2-Hydroxy-3′-O-methyladenosine, 2-phenylamino-N6,2-O-dimethyladenosine acts as an adenosine deaminase inhibitor with a Ki of 13 nM.

FR-221647 is a non-nucleoside adenosine deaminase inhibitor, it has moderate activity and good pharmacokinetics compared with the known inhibitors EHNA and pentostatin.

AMPD2 Inhibitor 2 is a potent inhibitor of AMP deaminase 2 (AMPD2), demonstrating inhibitory concentration 50 (IC50) values of 0.1 μM for human AMPD2 (hAMPD2) and 0.28 μM for mouse AMPD2 (mAMPD2). This compound is valuable for research into the physiological roles of AMPD2, especially in mice on a high-fat diet.

Coformycin is a ribonucleoside antibiotic synergist and adenosine deaminase inhibitor.

L-Adenosine is a useful organic compound for research related to life sciences. The catalog number is T65008 and the CAS number is 3080-29-3.

FR-234938 is a non-nucleoside adenosine deaminase inhibitor with anti-inflammatory activity.

EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) (IC50 = 4 μM) and adenosine deaminase (ADA). It exhibits concentration-dependent inhibition of cGMP-stimulated PDE2 activity, with IC50 values of 0.8 μM in humans and 2 μM in porcine myocardium, but shows limited inhibition on unstimulated PDE2. EHNA is involved in modulating various pharmacological responses, such as antiviral, antitumor, and antiarrhythmic effects.