Adenosine Deaminase

8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

EHNA hydrochloride is a selective inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA) with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner. EHNA hydrochloride inhibits PHA and NaI04 mitogenesis.

Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.

Pentostatin (CI-825) is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).

AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, useful for studying anorexia in the nervous system.

Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.

3'-O-Methyladenosine is an antiviral compound with inhibitory activity against West Nile Virus and can be used for the treatment of viral infections.3'-O-Methyladenosine inhibits adenosine deaminase type VII with a Ki value of 493 µM.

Erdosteine (RV 144) is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus production and viscosity, by which facilitating mucociliary transport and improving expectoration. This agent also suppresses the chemical-induced cough reflex as well as protects lung tissues from damages caused by cigarette smoking mediated through free radicals scavenging.

1-Deazaadenosine, a potent Adenosine deaminase inhibitor (Ki: 0.66 μM), exhibits anti-cancer activities in vitro and holds potential as a chemotherapy agent for lymphoproliferative disorders.

Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of 2'-deoxyadenosine and adenosine to 2'-deoxyinosine and inosine, respectively.

FR-221647 is a non-nucleoside adenosine deaminase inhibitor, it has moderate activity and good pharmacokinetics compared with the known inhibitors EHNA and pentostatin.

AMPD2 Inhibitor 2 is a potent inhibitor of AMP deaminase 2 (AMPD2), demonstrating inhibitory concentration 50 (IC50) values of 0.1 μM for human AMPD2 (hAMPD2) and 0.28 μM for mouse AMPD2 (mAMPD2). This compound is valuable for research into the physiological roles of AMPD2, especially in mice on a high-fat diet.

2-Hydroxy-3′-O-methyladenosine serves as a synthetic intermediate in the study of ischemic heart disease, cerebrovascular disease, kidney disease, inflammatory allergies, and more. Derived from 2-Hydroxy-3′-O-methyladenosine, 2-phenylamino-N6,2-O-dimethyladenosine acts as an adenosine deaminase inhibitor with a Ki of 13 nM.

L-Adenosine is a useful organic compound for research related to life sciences. The catalog number is T65008 and the CAS number is 3080-29-3.

Coformycin is a ribonucleoside antibiotic synergist and adenosine deaminase inhibitor.

FR-234938 is a non-nucleoside adenosine deaminase inhibitor with anti-inflammatory activity.