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CCT020312

Name: CCT020312
Brand: TargetMol
SKU: T14902
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14902Cas No. 324759-76-4

CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 µM.

CCT020312

🥰Excellent

Purity: 98.63%

Catalog No. T14902Cas No. 324759-76-4

CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 µM.

Pack Size	Price	Availability
1 mg	$56	In Stock
5 mg	$143	In Stock
10 mg	$253	In Stock
25 mg	$429	In Stock
50 mg	$635	In Stock
100 mg	$883	In Stock
500 mg	$1,830	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.63%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 µM.
In vitro	METHODS: CCT020312 (0-9 µM, 24 h) treated medium HT29 cells for 24 h. Ser608 pRB phosphorylation was quantified using a cell-based immunoassay. RESULTS Concentration-dependent loss of P-S608-pRB signaling was observed with linear response values between 1.8 and 6.1 µM. [1]
In vivo	METHODS: CCT020312 (2 mg/kg, intraperitoneal injection, starting at 17 weeks for 6 weeks) was used to treat P301S tau transgenic mice to test for mouse-specific visuospatial memory deficits. RESULTS P301S tau transgenic mice performed significantly better in the Morris water maze. [2]

Chemical Properties

Molecular Weight	650.4
Formula	C₃₁H₃₀Br₂N₄O₂
Cas No.	324759-76-4
Smiles	CCN(CC)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O
Relative Density.	1.48 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (222.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5375 mL	7.6876 mL	15.3752 mL	76.8758 mL
5 mM	0.3075 mL	1.5375 mL	3.0750 mL	15.3752 mL
10 mM	0.1538 mL	0.7688 mL	1.5375 mL	7.6876 mL
20 mM	0.0769 mL	0.3844 mL	0.7688 mL	3.8438 mL
50 mM	0.0308 mL	0.1538 mL	0.3075 mL	1.5375 mL
100 mM	0.0154 mL	0.0769 mL	0.1538 mL	0.7688 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc