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4-Vinylcyclohexene Dioxide

Name: 4-Vinylcyclohexene Dioxide
Brand: TargetMol
SKU: T64882
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: VCD, 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane) Copy Product Info

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Synonyms: VCD, 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane

Catalog No. T64882 Copy Product Info

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4-Vinylcyclohexene Dioxide (VCD) is an industrial epoxy resin intermediate and metabolite that exhibits a highly selective destructive effect on oocytes in primordial and primary follicles; it is used as a key inducer for establishing animal models of premature ovarian failure and premenopause. 4-Vinylcyclohexene Dioxide exerts its ovarian toxicity by activating caspase-dependent apoptotic pathways and can induce apoptosis in ovarian granulosa cells by upregulating reactive oxygen species and activating the PI3K/Akt/mTOR signaling pathway. It is used in reproductive toxicology and endocrine regulation research.

Cas No. 106-87-6

Pack Size	Price	USA Stock	Global Stock	Quantity
1 g	$40	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Liquid

Color:Transparent

Resource Download

COA MS HNMR

Product Introduction

Bioactivity

Description

Synonyms

VCD, 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane

Chemical Properties

Molecular Weight	140.18
Formula	C₈H₁₂O₂
Cas No.	106-87-6
Smiles	O1CC1C2CCC3OC3C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (285.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (35.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.1337 mL	35.6684 mL	71.3369 mL	356.6843 mL
5 mM	1.4267 mL	7.1337 mL	14.2674 mL	71.3369 mL
10 mM	0.7134 mL	3.5668 mL	7.1337 mL	35.6684 mL
20 mM	0.3567 mL	1.7834 mL	3.5668 mL	17.8342 mL
50 mM	0.1427 mL	0.7134 mL	1.4267 mL	7.1337 mL
100 mM	0.0713 mL	0.3567 mL	0.7134 mL	3.5668 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: 4-Vinylcyclohexene Dioxide chemical structure | 4-Vinylcyclohexene Dioxide formula | 4-Vinylcyclohexene Dioxide molecular weight