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Anti-NPC2 Antibody (1E285)
😃Good
Catalog No. TMAY-02566
Alias Niemann-Pick disease, type C2, HE1, AU045843, AA408070, 2700012J19Rik
Anti-NPC2 Antibody (1E285) is a Rabbit antibody targeting NPC2. Anti-NPC2 Antibody (1E285) can be used in WB,ELISA,IP.
Anti-NPC2 Antibody (1E285)
Anti-NPC2 Antibody (1E285)
😃Good
Catalog No. TMAY-02566Alias Niemann-Pick disease, type C2, HE1, AU045843, AA408070, 2700012J19Rik
Anti-NPC2 Antibody (1E285) is a Rabbit antibody targeting NPC2. Anti-NPC2 Antibody (1E285) can be used in WB,ELISA,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB, ELISA, IP Reactivity: Human |
| Alias | Niemann-Pick disease, type C2, HE1, AU045843, AA408070, 2700012J19Rik |
| Ig Type | Rabbit IgG |
| Clone | 1E285 |
| Reactivity | Human |
| Verified Activity | 1. NPC2-His was immunoprecipitated using: -Lane A:0.5 mg NIH-3T3 Whole Cell Lysate. -2 µL anti-NPC2-His rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose. -Primary antibody: -Anti-NPC2-His rabbit monoclonal antibody, at 1:100 dilution. -Secondary antibody: -Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution. -Developed using the odyssey technique. -Performed under reducing conditions. -Predicted band size: 17 kDa. -Observed band size: 19 kDa. 2. Anti-NPC2 rabbit monoclonal antibody at 1:500 dilution. -Lane A: Hela Whole Cell Lysate. -Lane B: NIH-3T3 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:17 kDa. -Observed band size:19 kDa |
| Application | WB,ELISA,IP |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:5000-1:10000; IP: 1-4 μL/mg of lysate |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human NPC2 (rh NPC2; TMPY-01114; NP_006423.1; Met1-Leu151). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human NPC2 Protein (TMPY-01114) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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