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S 17092

Name: S 17092
Brand: TargetMol
SKU: T61684
Rating: 4.5 (1 reviews)

(Synonyms: S 17092-1) Copy Product Info

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Synonyms: S 17092-1

Catalog No. T61684 Copy Product Info

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S 17092 (S 17092-1) is a highly potent, reversible, and orally active small-molecule inhibitor of brain peptidylprolyl endopeptidase (PEP), with a binding constant (Ki) of 1.5 nM and an IC₅₀ of 1.2 nM against recombinant human PEP. By slowing the degradation of various neuroactive peptides, including Substance P, thyrotropin-releasing hormone (TRH), and arginine vasopressin (AVP), S 17092 increases the levels of these peptides in the brain and improves age-related or drug-induced memory and cognitive impairments in various rodent and primate animal models. S 17092 has been used in studies related to Alzheimer’s disease and cognitive impairment to evaluate the role of PEP regulation in neural function.

Cas No. 176797-26-5

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Product Introduction

Bioactivity

Description

Synonyms

S 17092-1

Chemical Properties

Molecular Weight	384.53
Formula	C₂₂H₂₈N₂O₂S
Cas No.	176797-26-5
Smiles	C(=O)(N1[C@@]2([C@](C[C@H]1C(=O)N3CCSC3)(CCCC2)[H])[H])[C@H]4[C@@H](C4)C5=CC=CC=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (208.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6006 mL	13.0029 mL	26.0058 mL	130.0289 mL
5 mM	0.5201 mL	2.6006 mL	5.2012 mL	26.0058 mL
10 mM	0.2601 mL	1.3003 mL	2.6006 mL	13.0029 mL
20 mM	0.1300 mL	0.6501 mL	1.3003 mL	6.5014 mL
50 mM	0.0520 mL	0.2601 mL	0.5201 mL	2.6006 mL
100 mM	0.0260 mL	0.1300 mL	0.2601 mL	1.3003 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: S 17092 chemical structure | S 17092 formula | S 17092 molecular weight