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Tolnaftate

Name: Tolnaftate
Brand: TargetMol
SKU: T1094
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1094Cas No. 2398-96-1

Alias Tonoftal, Tinactin, Sporiline, NP-27

Tolnaftate (NP-27) is a synthetic antifungal agent used to treat skin infections caused by fungi.

Tolnaftate

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Purity: 98.85%

Catalog No. T1094Alias Tonoftal, Tinactin, Sporiline, NP-27Cas No. 2398-96-1

Tolnaftate (NP-27) is a synthetic antifungal agent used to treat skin infections caused by fungi.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.85%

Color:White

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COA HNMR LCMS

Product Introduction

Tolnaftate AI Summary

Tolnaftate exhibits high lipophilicity with partition coefficients (LogP) ranging between 5.15 and 5.4, indicating its propensity to interact with lipid membranes or proteins. It shows good retention in high-performance liquid chromatography, with a capacity factor (k) of Log k'w = 4.55. Additionally, its partition coefficient at pH 7.4 is LogD = 5.4. The compound demonstrates diverse bioactivities, including inhibition of human CYP51 enzyme activity with an IC50 value of 50 µM, and potent antifungal activity against Colletotrichum graminicola with ED50 values around 0.58 µg/ml. It also inhibits CYP450 2C19 and BSEP transporters with IC50 values of 3 µM and <10.32 µM, respectively. Moreover, Tolnaftate exhibits antiviral properties against SARS-CoV-2, inhibits its 3CL-Pro protease by 32.15% at 20 µM, and shows variable efficacy in cell-based assays. Its interaction with multiple receptors and enzymes, including moderate potency against Tyrosyl-DNA Phosphodiesterase and inhibitory effects on Cytochrome P450 enzymes, suggests potential roles in drug metabolism and signaling pathways. Furthermore, it exhibits fungicidal activity by inhibiting squalene accumulation and squalene epoxidase in various fungi. Despite its broad spectrum of bioactivities, the compound generally exhibits low to moderate potency in many assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tolnaftate (NP-27) is a synthetic antifungal agent used to treat skin infections caused by fungi.
Synonyms	Tonoftal, Tinactin, Sporiline, NP-27

Chemical Properties

Molecular Weight	307.41
Formula	C₁₉H₁₇NOS
Cas No.	2398-96-1
Smiles	O(C(N(C)C1=CC(C)=CC=C1)=S)C2=CC3=C(C=C2)C=CC=C3
Relative Density.	1.223 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 65 mg/mL (211.44 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (8.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2530 mL	16.2649 mL	32.5298 mL	162.6492 mL
5 mM	0.6506 mL	3.2530 mL	6.5060 mL	32.5298 mL
10 mM	0.3253 mL	1.6265 mL	3.2530 mL	16.2649 mL
20 mM	0.1626 mL	0.8132 mL	1.6265 mL	8.1325 mL
50 mM	0.0651 mL	0.3253 mL	0.6506 mL	3.2530 mL
100 mM	0.0325 mL	0.1626 mL	0.3253 mL	1.6265 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc