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BMS 195614

Catalog No. T22192 CAS 253310-42-8

Synonyms: BMS614

BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.

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BMS 195614, CAS 253310-42-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 181.00
5 mg	In stock	$ 418.00
10 mg	In stock	$ 619.00
25 mg	In stock	$ 988.00
50 mg	In stock	$ 1,330.00
100 mg	In stock	$ 1,780.00
500 mg	In stock	$ 3,580.00

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Purity: 97.7%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.
In vitro	BMS 195614 reversed the induction effect of selective RARα agonists, AM580, AM80 and BMS 194753 on differentiation of the acute promyelocytic leukemia cell lines, NB4 and HL60 [1]. Treatment with retinoic acid (RA) (1 uM) for 72 hrs significantly reduced T47D breast cancer cells migration. But RA in combination with BMS 195614 did not affect the cell movement [2]. In cells of a bovine stromal-vascular fraction from intramuscular fat, BMS 195614 significantly diminished the anti-adipogenic effect of ATRA [3].
In vivo	BMS 195614 displayed poor in vivo activity in mice when administered orally. Treatment with BMS 195614 at oral doses for 1 month showed no inhibition to spermatogenesis [4]. Oral administration of BMS 195614 did not suppress spermatogenesis in mice [5].

Synonyms	BMS614
Molecular Weight	448.51
Formula	C29H24N2O3
CAS No.	253310-42-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10.1 mg/mL (22.5 mM)

References and Literature

1. F. Christopher Zusi, Matthew V. Lorenzi and Valerie Vivat-Hannah. Selective retinoids and rexinoids in cancer therapy and chemoprevention. Drug Discovery Today, 2002, 7(23):1165-1174. 2. Flamini Marina Ines, Gauna Gisel Valeria, Sottile Mayra Lis, et al. Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor β. J. Cell. Mol. Med., 2014, 18(6): 1113-1123. 3. Nikolas Gunkel, Thorsten Meyer and John Michael Graettinger; N/A. Method of Modulating the Degree of Adipose Tissue Deposited Intramuscularly. US patent 20140094512A1. 2014 Apr. 3. 4. Sanny S. W. Chung, Rebecca A. D. Cuellar, Xiangyuan Wang, et al. Pharmacological Activity of Retinoic Acid Receptor Alpha-Selective Antagonists in Vitro and in Vivo. ACS Med. Chem. Lett., 2013, 4: 446-450. 5. Fern E. Murdoch and Erwin Goldberg. Male contraception: Another holy grail. Bioorg. Med. Chem. Lett., 2014, 24:419-424.

Related compound libraries

This product is contained In the following compound libraries：

Nuclear Receptor Compound Library Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

AGN 194310 AGN 192870 Ro 41-5253 Retinoic acid-d5 Oxybenzone Peretinoin BMS453 trifarotene

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS 195614 253310-42-8 Metabolism Retinoid Receptor BMS-614 BMS195614 BMS 614 BMS614 BMS-195614 inhibitor inhibit

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