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1-Hydroxy-2-naphthoic acid

Name: 1-Hydroxy-2-naphthoic acid
Brand: TargetMol
SKU: T4789
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4789Cas No. 86-48-6

Alias ALPHA-HYDROXYNAPHTHOIC ACID

1-Hydroxy-2-naphthoic acid (ALPHA-HYDROXYNAPHTHOIC ACID) is a Metabolite from phenanthrene degradation.

1-Hydroxy-2-naphthoic acid

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Purity: 99.85%

Catalog No. T4789Alias ALPHA-HYDROXYNAPHTHOIC ACIDCas No. 86-48-6

1-Hydroxy-2-naphthoic acid (ALPHA-HYDROXYNAPHTHOIC ACID) is a Metabolite from phenanthrene degradation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

1-Hydroxy-2-naphthoic acid AI Summary

1-Hydroxy-2-naphthoic acid has the ability to bind to the monoclonal antibody IgE (Lb4), with an association constant (LogKA) of 6.708, indicating a strong binding affinity that suggests potential bioactivity related to the immune response and allergic reactions. It inhibits PTP1B with an IC50 value of 850,000 nM and exhibits binding affinity to 6-His-tagged human LDHA with a dissociation constant (Kd) of 640,000 nM. 1-Hydroxy-2-naphthoic acid shows inhibition of full-length human recombinant LDHA with an IC50 greater than 500,000 nM. While it demonstrates no significant inhibition of the influenza A/WSN/1933 virus neuraminidase N1 and exhibits no antiviral activity against the same strain in MDCK cells, it shows a relatively neutral octanol-water distribution coefficient at pH 7.4 and 6.5, indicating balanced hydrophilic and lipophilic properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Hydroxy-2-naphthoic acid (ALPHA-HYDROXYNAPHTHOIC ACID) is a Metabolite from phenanthrene degradation.
Synonyms	ALPHA-HYDROXYNAPHTHOIC ACID

Chemical Properties

Molecular Weight	188.18
Formula	C₁₁H₈O₃
Cas No.	86-48-6
Smiles	OC(=O)C1=C(O)C2=CC=CC=C2C=C1
Relative Density.	1.399 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (132.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3141 mL	26.5703 mL	53.1406 mL	265.7031 mL
5 mM	1.0628 mL	5.3141 mL	10.6281 mL	53.1406 mL
10 mM	0.5314 mL	2.6570 mL	5.3141 mL	26.5703 mL
20 mM	0.2657 mL	1.3285 mL	2.6570 mL	13.2852 mL
50 mM	0.1063 mL	0.5314 mL	1.0628 mL	5.3141 mL
100 mM	0.0531 mL	0.2657 mL	0.5314 mL	2.6570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc