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Arg-Gly-Asp-Ser

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Catalog No. T10366Cas No. 91037-65-9
Alias RGDS peptide, Fibronectin tetrapeptide

Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found on fibronectin, fibrinogen α, and von Willebrand factor. It binds to integrins on the cell surface, inhibiting thrombin-induced platelet-fibrinogen interaction.

Arg-Gly-Asp-Ser
Other Forms of Arg-Gly-Asp-Ser:

Arg-Gly-Asp-Ser

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Purity: 98.29%
Catalog No. T10366Alias RGDS peptide, Fibronectin tetrapeptideCas No. 91037-65-9
Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found on fibronectin, fibrinogen α, and von Willebrand factor. It binds to integrins on the cell surface, inhibiting thrombin-induced platelet-fibrinogen interaction.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$31In StockIn Stock
10 mg$51In StockIn Stock
25 mg$94In StockIn Stock
50 mg$137In StockIn Stock
100 mg$197-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.29%
Appearance:Solid
Color:White
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COA HNMR HPLC MS

Product Introduction

Bioactivity
Description
Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found on fibronectin, fibrinogen α, and von Willebrand factor. It binds to integrins on the cell surface, inhibiting thrombin-induced platelet-fibrinogen interaction.
In vitro
Arg-Gly-Asp-Ser increases mRNA expression and secretion of TGF-β1 by stimulating the promoter of TGF-β1 gene. [1]
Cell binding to RGDS eliminates apoptosis through the mitochondrial pathway, and inhibition of apoptosis depends on the activity of phosphatidylinositol 3-kinase. [2]
In vivo
Arg-Gly-Asp-Ser (1, 2.5, or 5 mg/kg, intraperitoneally administered) inhibited LPS-induced increases in the number of neutrophils and macrophages, total protein levels, TNF-α and MIP-2 levels, and matrix metalloproteinase-9 activity in mouse bronchoalveolar lavage fluid (BAL). [3]
Arg-Gly-Asp-Ser almost completely inhibited lung colonization of intravenous PAK 17.15 cells in C57BL/6 mice. [4]
SynonymsRGDS peptide, Fibronectin tetrapeptide
Chemical Properties
Molecular Weight433.42
FormulaC15H27N7O8
Cas No.91037-65-9
Smiles[C@H](C(N[C@H](C(O)=O)CO)=O)(NC(CNC([C@H](CCCNC(=N)N)N)=O)=O)CC(O)=O
Relative Density.1.65g/cm3
SequenceArg-Gly-Asp-Ser
Sequence ShortRGDS
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (92.29 mM), Sonication is recommended.
H2O: 25 mg/mL (57.68 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.3072 mL11.5362 mL23.0723 mL115.3615 mL
5 mM0.4614 mL2.3072 mL4.6145 mL23.0723 mL
10 mM0.2307 mL1.1536 mL2.3072 mL11.5362 mL
20 mM0.1154 mL0.5768 mL1.1536 mL5.7681 mL
50 mM0.0461 mL0.2307 mL0.4614 mL2.3072 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Arg-Gly-Asp-SerArgGlyAspSerArg Gly Asp Ser
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