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Arg-Gly-Asp-Ser

Arg-Gly-Asp-Ser
Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function, thereby decreasing systemic inflammation by inhibiting collagen-triggered activation of leukocytes and attenuating the expression of inflammatory cytokines, MMP-9, and iNOS.
Catalog No. T10366Cas No. 91037-65-9

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Arg-Gly-Asp-Ser

Catalog No. T10366Cas No. 91037-65-9

Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function, thereby decreasing systemic inflammation by inhibiting collagen-triggered activation of leukocytes and attenuating the expression of inflammatory cytokines, MMP-9, and iNOS.
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Product Introduction

Bioactivity
Description
Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function, thereby decreasing systemic inflammation by inhibiting collagen-triggered activation of leukocytes and attenuating the expression of inflammatory cytokines, MMP-9, and iNOS.
In vitro
The Arg-Gly-Asp-Ser-modified surface up-regulates αvβ3 integrin and completely abolishes apoptosis induced by staurosporine, the Ca2+·Pi ion pair, and sodium nitroprusside upon attachment. The resistance to apoptosis, dependent on Arg-Gly-Asp-Ser, is eliminated when the phosphatidylinositol 3-kinase pathway is inhibited [1]. Arg-Gly-Asp-Ser interacts with survivin and procaspase-3, -8, and -9, with specific, high-affinity binding (Kd: 27.5 μM) to the C-terminus of survivin [4].
In vivo
Administering Arg-Gly-Asp-Ser at doses of 2.5 or 5 mg/kg, one hour before lipopolysaccharide (LPS), significantly inhibits LPS-induced matrix metallopeptidase-9 (MMP-9) activity in bronchoalveolar lavage (BAL) fluid four hours after LPS exposure. Similarly, Arg-Gly-Asp-Ser given intraperitoneally (i.p.) at doses of 1, 2.5, or 5 mg/kg, one hour before LPS, effectively suppressed the LPS-induced increases in tumor necrosis factor-alpha (TNF-α) and macrophage inflammatory protein (MIP)-2 levels in BAL fluid at the four-hour mark post-LPS [2]. Furthermore, the Arg-Gly-Asp-Ser peptide significantly lowers TNF-α and MIP-2 production and reduces myeloperoxidase (MPO) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity [3].
AliasFibronectin tetrapeptide, RGDS peptide
Chemical Properties
Molecular Weight433.42
FormulaC15H27N7O8
Cas No.91037-65-9
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 25 mg/mL (57.68 mM)
DMSO: 55 mg/mL (126.90 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.3072 mL11.5362 mL23.0723 mL115.3615 mL
5 mM0.4614 mL2.3072 mL4.6145 mL23.0723 mL
10 mM0.2307 mL1.1536 mL2.3072 mL11.5362 mL
20 mM0.1154 mL0.5768 mL1.1536 mL5.7681 mL
50 mM0.0461 mL0.2307 mL0.4614 mL2.3072 mL
DMSO
1mg5mg10mg50mg
100 mM0.0231 mL0.1154 mL0.2307 mL1.1536 mL

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